Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences
Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans an...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2013-01, Vol.10 (3), p.410-417 |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Herrera-Arellano, Armando López-Villegas, Edgar O Rodríguez-Tovar, Aida V Zamilpa, Alejandro Jiménez-Ferrer, Enrique Tortoriello, Jaime Martínez-Rivera, M Angeles |
| description | Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X(2), p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC. |
| doi_str_mv | 10.4314/ajtcam.v10i3.4 |
| format | Article |
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Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X(2), p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 2505-0044</identifier><identifier>EISSN: 0189-6016</identifier><identifier>DOI: 10.4314/ajtcam.v10i3.4</identifier><identifier>PMID: 24146467</identifier><language>eng</language><publisher>Nigeria: African Networks on Ethnomedicines</publisher><subject>Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Candida albicans - drug effects ; Candida albicans - ultrastructure ; Candidiasis, Vulvovaginal - drug therapy ; Candidiasis, Vulvovaginal - microbiology ; Double-Blind Method ; Female ; Humans ; Ketoconazole - therapeutic use ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Review ; Saponins - pharmacology ; Saponins - therapeutic use ; Solanum - chemistry ; Treatment Outcome</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2013-01, Vol.10 (3), p.410-417</ispartof><rights>Copyright © Afr. 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Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X(2), p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC.</description><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - ultrastructure</subject><subject>Candidiasis, Vulvovaginal - drug therapy</subject><subject>Candidiasis, Vulvovaginal - microbiology</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Ketoconazole - therapeutic use</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Review</subject><subject>Saponins - pharmacology</subject><subject>Saponins - therapeutic use</subject><subject>Solanum - chemistry</subject><subject>Treatment Outcome</subject><issn>0189-6016</issn><issn>2505-0044</issn><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi1ERZctV47IRy5Z7NiJHQ5IaMWXVKmHtmdr6kx2XSX2YjtR-y_4yXjZUsFpNDOP3vl4CXnL2UYKLj_AfbYwbRbOnNjIF2RVN6ypGJPyJVkxrruqZbw9J69TumdMaF6rV-S8lly2slUr8us2IQ0DBZ_dMPsdjDTBIXjn6fW2qo-t6zCCnydq9_ExhRyd3ZdsCJHmPdIcEfKEPh_RZR6XsMDO-aJjwfeud5Bc-kiL3uJyDDTluXeYysCe2tF5ZwuKDweMDr3FdEHOBhgTvnmKa3L79cvN9nt1efXtx_bzZWVFw3KlrWYKsLM4KMnL0Zp3Uui2qQVDVTcCBt6wDsGKrmPNwLoaNfbAUAtxZ4VYk08n3cN8N2FvywURRnOIboL4aAI483_Hu73ZhcUIpVSjuiLw_kkghp8zpmwmlyyO5VkY5mSOH9Zd2Y0XdHNCbQwpRRyex3Bmjjaak43mj42lsibv_l3uGf_rm_gNMROedA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Herrera-Arellano, Armando</creator><creator>López-Villegas, Edgar O</creator><creator>Rodríguez-Tovar, Aida V</creator><creator>Zamilpa, Alejandro</creator><creator>Jiménez-Ferrer, Enrique</creator><creator>Tortoriello, Jaime</creator><creator>Martínez-Rivera, M Angeles</creator><general>African Networks on Ethnomedicines</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences</title><author>Herrera-Arellano, Armando ; López-Villegas, Edgar O ; Rodríguez-Tovar, Aida V ; Zamilpa, Alejandro ; Jiménez-Ferrer, Enrique ; Tortoriello, Jaime ; Martínez-Rivera, M Angeles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-8c807ae9cef74125081943865230e7253af1509eac39905f092e8eda0e833bc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - ultrastructure</topic><topic>Candidiasis, Vulvovaginal - drug therapy</topic><topic>Candidiasis, Vulvovaginal - microbiology</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Ketoconazole - therapeutic use</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Review</topic><topic>Saponins - pharmacology</topic><topic>Saponins - therapeutic use</topic><topic>Solanum - chemistry</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herrera-Arellano, Armando</creatorcontrib><creatorcontrib>López-Villegas, Edgar O</creatorcontrib><creatorcontrib>Rodríguez-Tovar, Aida V</creatorcontrib><creatorcontrib>Zamilpa, Alejandro</creatorcontrib><creatorcontrib>Jiménez-Ferrer, Enrique</creatorcontrib><creatorcontrib>Tortoriello, Jaime</creatorcontrib><creatorcontrib>Martínez-Rivera, M Angeles</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrera-Arellano, Armando</au><au>López-Villegas, Edgar O</au><au>Rodríguez-Tovar, Aida V</au><au>Zamilpa, Alejandro</au><au>Jiménez-Ferrer, Enrique</au><au>Tortoriello, Jaime</au><au>Martínez-Rivera, M Angeles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><addtitle>Afr J Tradit Complement Altern Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>10</volume><issue>3</issue><spage>410</spage><epage>417</epage><pages>410-417</pages><issn>0189-6016</issn><eissn>2505-0044</eissn><eissn>0189-6016</eissn><abstract>Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X(2), p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. 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| ispartof | African journal of traditional, complementary, and alternative medicines, 2013-01, Vol.10 (3), p.410-417 |
| issn | 0189-6016 2505-0044 0189-6016 |
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| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Candida albicans - drug effects Candida albicans - ultrastructure Candidiasis, Vulvovaginal - drug therapy Candidiasis, Vulvovaginal - microbiology Double-Blind Method Female Humans Ketoconazole - therapeutic use Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Review Saponins - pharmacology Saponins - therapeutic use Solanum - chemistry Treatment Outcome |
| title | Use of antifungal saponin SC-2 of Solanum chrysotrichum for the treatment of vulvovaginal candidiasis: in vitro studies and clinical experiences |
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