Magnetic Nanoparticle Quantitation with Low Frequency Magnetic Fields: Compensating for Relaxation Effects
Quantifying the number of nanoparticles present in tissue is central to many in vivo and in vitro applications. Magnetic nanoparticles can be detected with high sensitivity both in vivo and in vitro using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxati...
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| Veröffentlicht in: | Nanotechnology 2013-07, Vol.24 (32), p.325502-325502 |
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| container_title | Nanotechnology |
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| creator | Weaver, John B. Zhang, Xiaojuan Kuehlert, Esra Toraya-Brown, Seiko Reeves, Daniel B. Perreard, Irina M. Fiering, Steven N. |
| description | Quantifying the number of nanoparticles present in tissue is central to many
in vivo
and
in vitro
applications. Magnetic nanoparticles can be detected with high sensitivity both
in vivo
and
in vitro
using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxation effects damp the magnetic harmonics rendering them of limited use in quantitation. We show that an accurate measure of the number of nanoparticles can be made by correcting for relaxation effects. Correction for relaxation reduced errors of 50% for larger nanoparticles in high relaxation environments to 2%. The result is a method of nanoparticle quantitation capable of
in vivo
and
in vitro
applications including histopathology assays, quantitative imaging, drug delivery and thermal therapy preparation. |
| doi_str_mv | 10.1088/0957-4484/24/32/325502 |
| format | Article |
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in vivo
and
in vitro
applications. Magnetic nanoparticles can be detected with high sensitivity both
in vivo
and
in vitro
using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxation effects damp the magnetic harmonics rendering them of limited use in quantitation. We show that an accurate measure of the number of nanoparticles can be made by correcting for relaxation effects. Correction for relaxation reduced errors of 50% for larger nanoparticles in high relaxation environments to 2%. The result is a method of nanoparticle quantitation capable of
in vivo
and
in vitro
applications including histopathology assays, quantitative imaging, drug delivery and thermal therapy preparation.</description><identifier>ISSN: 0957-4484</identifier><identifier>EISSN: 1361-6528</identifier><identifier>DOI: 10.1088/0957-4484/24/32/325502</identifier><identifier>PMID: 23867287</identifier><language>eng</language><ispartof>Nanotechnology, 2013-07, Vol.24 (32), p.325502-325502</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Weaver, John B.</creatorcontrib><creatorcontrib>Zhang, Xiaojuan</creatorcontrib><creatorcontrib>Kuehlert, Esra</creatorcontrib><creatorcontrib>Toraya-Brown, Seiko</creatorcontrib><creatorcontrib>Reeves, Daniel B.</creatorcontrib><creatorcontrib>Perreard, Irina M.</creatorcontrib><creatorcontrib>Fiering, Steven N.</creatorcontrib><title>Magnetic Nanoparticle Quantitation with Low Frequency Magnetic Fields: Compensating for Relaxation Effects</title><title>Nanotechnology</title><description>Quantifying the number of nanoparticles present in tissue is central to many
in vivo
and
in vitro
applications. Magnetic nanoparticles can be detected with high sensitivity both
in vivo
and
in vitro
using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxation effects damp the magnetic harmonics rendering them of limited use in quantitation. We show that an accurate measure of the number of nanoparticles can be made by correcting for relaxation effects. Correction for relaxation reduced errors of 50% for larger nanoparticles in high relaxation environments to 2%. The result is a method of nanoparticle quantitation capable of
in vivo
and
in vitro
applications including histopathology assays, quantitative imaging, drug delivery and thermal therapy preparation.</description><issn>0957-4484</issn><issn>1361-6528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqljM1KxDAcxIMobv14BckL1OarTfTgZdmyBxUU7yF2_-1maZOapK779haUBc_CwAzM_AahG0puKVGqIHelzIVQomCi4GxWWRJ2gjLKK5pXJVOnKDuOFugixh0hlCpGz9GCcVVJpmSGdk-mc5Bsg5-N86MJc-wBv0zGJZtMst7hvU1b_Oj3uA7wMYFrDvhI1Rb6TbzHSz-M4OIMuA63PuBX6M3XD79qW2hSvEJnrekjXP_6JXqoV2_LdT5O7wNsGnApmF6PwQ4mHLQ3Vv9tnN3qzn9qLqUUouT_PvgGF0RpYQ</recordid><startdate>20130718</startdate><enddate>20130718</enddate><creator>Weaver, John B.</creator><creator>Zhang, Xiaojuan</creator><creator>Kuehlert, Esra</creator><creator>Toraya-Brown, Seiko</creator><creator>Reeves, Daniel B.</creator><creator>Perreard, Irina M.</creator><creator>Fiering, Steven N.</creator><scope>5PM</scope></search><sort><creationdate>20130718</creationdate><title>Magnetic Nanoparticle Quantitation with Low Frequency Magnetic Fields: Compensating for Relaxation Effects</title><author>Weaver, John B. ; Zhang, Xiaojuan ; Kuehlert, Esra ; Toraya-Brown, Seiko ; Reeves, Daniel B. ; Perreard, Irina M. ; Fiering, Steven N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_37774453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weaver, John B.</creatorcontrib><creatorcontrib>Zhang, Xiaojuan</creatorcontrib><creatorcontrib>Kuehlert, Esra</creatorcontrib><creatorcontrib>Toraya-Brown, Seiko</creatorcontrib><creatorcontrib>Reeves, Daniel B.</creatorcontrib><creatorcontrib>Perreard, Irina M.</creatorcontrib><creatorcontrib>Fiering, Steven N.</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nanotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weaver, John B.</au><au>Zhang, Xiaojuan</au><au>Kuehlert, Esra</au><au>Toraya-Brown, Seiko</au><au>Reeves, Daniel B.</au><au>Perreard, Irina M.</au><au>Fiering, Steven N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Nanoparticle Quantitation with Low Frequency Magnetic Fields: Compensating for Relaxation Effects</atitle><jtitle>Nanotechnology</jtitle><date>2013-07-18</date><risdate>2013</risdate><volume>24</volume><issue>32</issue><spage>325502</spage><epage>325502</epage><pages>325502-325502</pages><issn>0957-4484</issn><eissn>1361-6528</eissn><abstract>Quantifying the number of nanoparticles present in tissue is central to many
in vivo
and
in vitro
applications. Magnetic nanoparticles can be detected with high sensitivity both
in vivo
and
in vitro
using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxation effects damp the magnetic harmonics rendering them of limited use in quantitation. We show that an accurate measure of the number of nanoparticles can be made by correcting for relaxation effects. Correction for relaxation reduced errors of 50% for larger nanoparticles in high relaxation environments to 2%. The result is a method of nanoparticle quantitation capable of
in vivo
and
in vitro
applications including histopathology assays, quantitative imaging, drug delivery and thermal therapy preparation.</abstract><pmid>23867287</pmid><doi>10.1088/0957-4484/24/32/325502</doi></addata></record> |
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| ispartof | Nanotechnology, 2013-07, Vol.24 (32), p.325502-325502 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3777445 |
| source | Institute of Physics Journals |
| title | Magnetic Nanoparticle Quantitation with Low Frequency Magnetic Fields: Compensating for Relaxation Effects |
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