Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response

Summary The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been used as a tool to lower intracellular cAMP levels and thereby elucidate the roles of cAMP in mycobacteria. Here we show that levels of cAMP i...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2013-09, Vol.93 (5), p.492-500
Hauptverfasser:	Matange, Nishad, Hunt, Debbie M, Buxton, Roger S, Visweswariah, Sandhya S
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - biosynthesis 3',5'-Cyclic-AMP Phosphodiesterases - genetics 3',5'-Cyclic-AMP Phosphodiesterases - physiology Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Bacterial Proteins - physiology Catalysis Cyclic AMP Cyclic AMP - biosynthesis Cyclic AMP - physiology Cyclic AMP Receptor Protein - deficiency Cyclic AMP Receptor Protein - genetics Gene Expression Regulation, Bacterial - physiology Gene Knockout Techniques Genes, Bacterial Humans Infectious Disease Microarray Molecular Aspects Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis - physiology Oligonucleotide Array Sequence Analysis - methods Phosphodiesterase Promoter Regions, Genetic - genetics Pulmonary/Respiratory Rv0805 Transcription, Genetic Transcriptome
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