High Prevalence of Vitamin D Deficiency in Patients With Basal Cell Nevus Syndrome
OBJECTIVES To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency. DESIGN Retrospective cohort study. SETTING Academic medical centers. PATIENTS Fo...
Gespeichert in:
| Veröffentlicht in: | Archives of dermatology (1960) 2010-10, Vol.146 (10), p.1105-1110 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1110 |
|---|---|
| container_issue | 10 |
| container_start_page | 1105 |
| container_title | Archives of dermatology (1960) |
| container_volume | 146 |
| creator | Tang, Jean Y Wu, Angela Linos, Eleni Parimi, Neeta Lee, Wayne Aszterbaum, Michelle Asgari, Maryam M Bickers, David R Epstein, Ervin H |
| description | OBJECTIVES To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency. DESIGN Retrospective cohort study. SETTING Academic medical centers. PATIENTS Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography. MAIN OUTCOME MEASURES Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL). RESULTS Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (−3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P |
| doi_str_mv | 10.1001/archdermatol.2010.247 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3775573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>422132</ama_id><sourcerecordid>2170729301</sourcerecordid><originalsourceid>FETCH-LOGICAL-a485t-bb3deb5d4ce97bfed49cf7bf027b0db997cba5b85ce366e77357e0b0b6491cd93</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhi0EosvCD-AAspAQpxTHjuP4ggRboEgVVHzfrLEz6bpK4mInK-2_x6tdlsLJ45ln3pnRS8iTkp2WjJUvIbp1i3GAKfSnnOU0r9QdsiilaApRS36XLBhjotCN-nlCHqR0ndt40_D75IQzLeu6Khfk87m_WtPLiBvocXRIQ0e_-wkGP9Izeoaddz7ntzT_L2HK8ZToDz-t6RtI0NMV9j39iJs50S_bsY1hwIfkXgd9wkeHd0m-vXv7dXVeXHx6_2H1-qKAqpFTYa1o0cq2cqiV7bCttOtywLiyrLVaK2dB2kY6FHWNSgmpkFlm60qXrtViSV7tdW9mO2Dr8moRenMT_QBxawJ4829l9GtzFTZGKCWlElngxUEghl8zpskMPrl8EIwY5mSU1IJXO3RJnv1HXoc5jvm6HZQXUg3LkNxDLoaUInbHVUpmdp6Z256ZnWcme5b7nt6-49j1x6QMPD8AkBz0XYTR-fSXEzzP5zJzj_ccDHCsVpyXgovfxBOsrQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>759649780</pqid></control><display><type>article</type><title>High Prevalence of Vitamin D Deficiency in Patients With Basal Cell Nevus Syndrome</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Tang, Jean Y ; Wu, Angela ; Linos, Eleni ; Parimi, Neeta ; Lee, Wayne ; Aszterbaum, Michelle ; Asgari, Maryam M ; Bickers, David R ; Epstein, Ervin H</creator><creatorcontrib>Tang, Jean Y ; Wu, Angela ; Linos, Eleni ; Parimi, Neeta ; Lee, Wayne ; Aszterbaum, Michelle ; Asgari, Maryam M ; Bickers, David R ; Epstein, Ervin H</creatorcontrib><description>OBJECTIVES To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency. DESIGN Retrospective cohort study. SETTING Academic medical centers. PATIENTS Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography. MAIN OUTCOME MEASURES Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL). RESULTS Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (−3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P < .001). Levels of 25(OH)D were lower in patients who were overweight (−3.0 ng/mL; P = .04) and who had blood collected in the winter compared with the summer (−7.1 ng/mL; P < .001). CONCLUSION Patients with BCNS may be at increased risk for vitamin D deficiency, depending on their adherence to photoprotection practices. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00023621Arch Dermatol" year="2010" volume="146" issueno="10" page="1105-1110"--></description><identifier>ISSN: 0003-987X</identifier><identifier>ISSN: 2168-6068</identifier><identifier>EISSN: 1538-3652</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/archdermatol.2010.247</identifier><identifier>PMID: 20956641</identifier><identifier>CODEN: ARDEAC</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Basal Cell Nevus Syndrome - blood ; Basal Cell Nevus Syndrome - complications ; Biological and medical sciences ; Cohort Studies ; Dermatology ; Epidemiology ; Female ; General aspects ; Genetics ; Humans ; Male ; Medical sciences ; Prevalence ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Risk factors ; Skin cancer ; Skin Neoplasms - blood ; Skin Neoplasms - complications ; Tumors of the skin and soft tissue. Premalignant lesions ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - etiology ; Vitamin deficiency</subject><ispartof>Archives of dermatology (1960), 2010-10, Vol.146 (10), p.1105-1110</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Medical Association Oct 2010</rights><rights>2010 American Medical Association. All rights reserved. 2010</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a485t-bb3deb5d4ce97bfed49cf7bf027b0db997cba5b85ce366e77357e0b0b6491cd93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/archdermatol.2010.247$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archdermatol.2010.247$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,776,780,881,3327,27901,27902,76232,76235</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23297825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20956641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Jean Y</creatorcontrib><creatorcontrib>Wu, Angela</creatorcontrib><creatorcontrib>Linos, Eleni</creatorcontrib><creatorcontrib>Parimi, Neeta</creatorcontrib><creatorcontrib>Lee, Wayne</creatorcontrib><creatorcontrib>Aszterbaum, Michelle</creatorcontrib><creatorcontrib>Asgari, Maryam M</creatorcontrib><creatorcontrib>Bickers, David R</creatorcontrib><creatorcontrib>Epstein, Ervin H</creatorcontrib><title>High Prevalence of Vitamin D Deficiency in Patients With Basal Cell Nevus Syndrome</title><title>Archives of dermatology (1960)</title><addtitle>Arch Dermatol</addtitle><description>OBJECTIVES To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency. DESIGN Retrospective cohort study. SETTING Academic medical centers. PATIENTS Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography. MAIN OUTCOME MEASURES Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL). RESULTS Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (−3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P < .001). Levels of 25(OH)D were lower in patients who were overweight (−3.0 ng/mL; P = .04) and who had blood collected in the winter compared with the summer (−7.1 ng/mL; P < .001). CONCLUSION Patients with BCNS may be at increased risk for vitamin D deficiency, depending on their adherence to photoprotection practices. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00023621Arch Dermatol" year="2010" volume="146" issueno="10" page="1105-1110"--></description><subject>Adult</subject><subject>Basal Cell Nevus Syndrome - blood</subject><subject>Basal Cell Nevus Syndrome - complications</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Dermatology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prevalence</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - blood</subject><subject>Skin Neoplasms - complications</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - etiology</subject><subject>Vitamin deficiency</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EosvCD-AAspAQpxTHjuP4ggRboEgVVHzfrLEz6bpK4mInK-2_x6tdlsLJ45ln3pnRS8iTkp2WjJUvIbp1i3GAKfSnnOU0r9QdsiilaApRS36XLBhjotCN-nlCHqR0ndt40_D75IQzLeu6Khfk87m_WtPLiBvocXRIQ0e_-wkGP9Izeoaddz7ntzT_L2HK8ZToDz-t6RtI0NMV9j39iJs50S_bsY1hwIfkXgd9wkeHd0m-vXv7dXVeXHx6_2H1-qKAqpFTYa1o0cq2cqiV7bCttOtywLiyrLVaK2dB2kY6FHWNSgmpkFlm60qXrtViSV7tdW9mO2Dr8moRenMT_QBxawJ4829l9GtzFTZGKCWlElngxUEghl8zpskMPrl8EIwY5mSU1IJXO3RJnv1HXoc5jvm6HZQXUg3LkNxDLoaUInbHVUpmdp6Z256ZnWcme5b7nt6-49j1x6QMPD8AkBz0XYTR-fSXEzzP5zJzj_ccDHCsVpyXgovfxBOsrQ</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Tang, Jean Y</creator><creator>Wu, Angela</creator><creator>Linos, Eleni</creator><creator>Parimi, Neeta</creator><creator>Lee, Wayne</creator><creator>Aszterbaum, Michelle</creator><creator>Asgari, Maryam M</creator><creator>Bickers, David R</creator><creator>Epstein, Ervin H</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101001</creationdate><title>High Prevalence of Vitamin D Deficiency in Patients With Basal Cell Nevus Syndrome</title><author>Tang, Jean Y ; Wu, Angela ; Linos, Eleni ; Parimi, Neeta ; Lee, Wayne ; Aszterbaum, Michelle ; Asgari, Maryam M ; Bickers, David R ; Epstein, Ervin H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a485t-bb3deb5d4ce97bfed49cf7bf027b0db997cba5b85ce366e77357e0b0b6491cd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Basal Cell Nevus Syndrome - blood</topic><topic>Basal Cell Nevus Syndrome - complications</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Dermatology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prevalence</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - blood</topic><topic>Skin Neoplasms - complications</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - etiology</topic><topic>Vitamin deficiency</topic><toplevel>online_resources</toplevel><creatorcontrib>Tang, Jean Y</creatorcontrib><creatorcontrib>Wu, Angela</creatorcontrib><creatorcontrib>Linos, Eleni</creatorcontrib><creatorcontrib>Parimi, Neeta</creatorcontrib><creatorcontrib>Lee, Wayne</creatorcontrib><creatorcontrib>Aszterbaum, Michelle</creatorcontrib><creatorcontrib>Asgari, Maryam M</creatorcontrib><creatorcontrib>Bickers, David R</creatorcontrib><creatorcontrib>Epstein, Ervin H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of dermatology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Jean Y</au><au>Wu, Angela</au><au>Linos, Eleni</au><au>Parimi, Neeta</au><au>Lee, Wayne</au><au>Aszterbaum, Michelle</au><au>Asgari, Maryam M</au><au>Bickers, David R</au><au>Epstein, Ervin H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Prevalence of Vitamin D Deficiency in Patients With Basal Cell Nevus Syndrome</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>Arch Dermatol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>146</volume><issue>10</issue><spage>1105</spage><epage>1110</epage><pages>1105-1110</pages><issn>0003-987X</issn><issn>2168-6068</issn><eissn>1538-3652</eissn><eissn>2168-6084</eissn><coden>ARDEAC</coden><abstract>OBJECTIVES To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency. DESIGN Retrospective cohort study. SETTING Academic medical centers. PATIENTS Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography. MAIN OUTCOME MEASURES Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL). RESULTS Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (−3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P < .001). Levels of 25(OH)D were lower in patients who were overweight (−3.0 ng/mL; P = .04) and who had blood collected in the winter compared with the summer (−7.1 ng/mL; P < .001). CONCLUSION Patients with BCNS may be at increased risk for vitamin D deficiency, depending on their adherence to photoprotection practices. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00023621Arch Dermatol" year="2010" volume="146" issueno="10" page="1105-1110"--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>20956641</pmid><doi>10.1001/archdermatol.2010.247</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-987X |
| ispartof | Archives of dermatology (1960), 2010-10, Vol.146 (10), p.1105-1110 |
| issn | 0003-987X 2168-6068 1538-3652 2168-6084 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3775573 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adult Basal Cell Nevus Syndrome - blood Basal Cell Nevus Syndrome - complications Biological and medical sciences Cohort Studies Dermatology Epidemiology Female General aspects Genetics Humans Male Medical sciences Prevalence Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk factors Skin cancer Skin Neoplasms - blood Skin Neoplasms - complications Tumors of the skin and soft tissue. Premalignant lesions Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology Vitamin D Deficiency - etiology Vitamin deficiency |
| title | High Prevalence of Vitamin D Deficiency in Patients With Basal Cell Nevus Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T03%3A38%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20Prevalence%20of%20Vitamin%20D%20Deficiency%20in%20Patients%20With%20Basal%20Cell%20Nevus%20Syndrome&rft.jtitle=Archives%20of%20dermatology%20(1960)&rft.au=Tang,%20Jean%20Y&rft.date=2010-10-01&rft.volume=146&rft.issue=10&rft.spage=1105&rft.epage=1110&rft.pages=1105-1110&rft.issn=0003-987X&rft.eissn=1538-3652&rft.coden=ARDEAC&rft_id=info:doi/10.1001/archdermatol.2010.247&rft_dat=%3Cproquest_pubme%3E2170729301%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=759649780&rft_id=info:pmid/20956641&rft_ama_id=422132&rfr_iscdi=true |