The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC

Abstract Type 1 Diabetes (T1D) is an autoimmune disorder characterized by aberrant T cell responses. Innate immune activation defects may facilitate a T helper 1 (Th1) phenotype. The cytokine IL-18 synergizes with IL-12 to induce IFNγ production and Th1 differentiation. The IL-18R subunit (IL18RAP)...

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Veröffentlicht in:	Journal of autoimmunity 2013-08, Vol.44, p.8-12
Hauptverfasser:	Myhr, Courtney B, Hulme, Maigan A, Wasserfall, Clive H, Hong, Peter J, Lakshmi, Priya Saikumar, Schatz, Desmond A, Haller, Michael J, Brusko, Todd M, Atkinson, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Allergy and Immunology Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmunity Biological and medical sciences Celiac disease Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Genetic Predisposition to Disease Genome wide association Genotype Humans IL-18 Interferon-gamma - biosynthesis Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-12 - biosynthesis Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-12 - pharmacology Interleukin-18 - biosynthesis Interleukin-18 - genetics Interleukin-18 - immunology Interleukin-18 - pharmacology Interleukin-18 Receptor beta Subunit - genetics Interleukin-18 Receptor beta Subunit - immunology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Leukocytes, Mononuclear - immunology Medical sciences NK cells Other diseases. Semiology Polymorphism, Single Nucleotide Stomach. Duodenum. Small intestine. Colon. Rectum. Anus T-Lymphocytes - immunology T-Lymphocytes - metabolism Type 1 diabetes
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