COMT-Val158Met-Polymorphism Is Not a Risk Factor for Acute Kidney Injury after Cardiac Surgery
Background. Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB). Objective. CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to b...
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| Veröffentlicht in: | Disease markers 2013-01, Vol.2013 (2013), p.1-6 |
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| creator | Boehm, Johannes Krane, M. Wagenpfeil, Stefan Lahm, H. Eichhorn, S. Deutsch, Marcus-André Kornek, Matthias Lange, R. |
| description | Background. Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB). Objective. CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to be causal for CSA-AKI. While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Pilot studies found associations between those COMT genotypes and CSA-AKI. Methods. We prospectively included 1741 patients undergoing elective cardiac surgery using cardiopulmonary bypass (CPB). Patients were genotyped for COMT-Val158Met-(G/A) polymorphism (rs4680). Results. Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between COMT genotypes and the RIFLE criteria could be detected. A multiple linear regression analysis for postoperative creatinine increase revealed highly significant associations for aortic cross-clamp time (P |
| doi_str_mv | 10.1155/2013/279046 |
| format | Article |
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Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB). Objective. CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to be causal for CSA-AKI. While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Pilot studies found associations between those COMT genotypes and CSA-AKI. Methods. We prospectively included 1741 patients undergoing elective cardiac surgery using cardiopulmonary bypass (CPB). Patients were genotyped for COMT-Val158Met-(G/A) polymorphism (rs4680). Results. Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between COMT genotypes and the RIFLE criteria could be detected. A multiple linear regression analysis for postoperative creatinine increase revealed highly significant associations for aortic cross-clamp time (P<0.001), CPB time (P<0.001), norepinephrine (P<0.001), and age (P<0.001). No associations were found for COMT genotypes or baseline creatinine. With an R2=0.39 and a sample size of 1741, the observed power of the regression analysis was >99%. Conclusions. Based on our results, we can rule out an association between the COMT-Val158Met-(G/A) polymorphism and the appearance of CSA-AKI.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2013/279046</identifier><identifier>PMID: 24167357</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - genetics ; Aged ; Amino Acid Substitution ; Cardiopulmonary Bypass ; Catechol O-Methyltransferase - genetics ; Creatinine - blood ; Female ; Genetic Association Studies ; Heart Diseases - surgery ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Postoperative Complications - blood ; Postoperative Complications - genetics ; Prospective Studies ; Risk Factors</subject><ispartof>Disease markers, 2013-01, Vol.2013 (2013), p.1-6</ispartof><rights>Copyright © 2013 Matthias Kornek et al.</rights><rights>Copyright © 2013 Matthias Kornek et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-9202-9737 ; 0000-0002-6845-2332 ; 0000-0003-1369-6425 ; 0000-0002-9128-2220</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24167357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chaudhry, Kishore</contributor><creatorcontrib>Boehm, Johannes</creatorcontrib><creatorcontrib>Krane, M.</creatorcontrib><creatorcontrib>Wagenpfeil, Stefan</creatorcontrib><creatorcontrib>Lahm, H.</creatorcontrib><creatorcontrib>Eichhorn, S.</creatorcontrib><creatorcontrib>Deutsch, Marcus-André</creatorcontrib><creatorcontrib>Kornek, Matthias</creatorcontrib><creatorcontrib>Lange, R.</creatorcontrib><title>COMT-Val158Met-Polymorphism Is Not a Risk Factor for Acute Kidney Injury after Cardiac Surgery</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB). Objective. CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to be causal for CSA-AKI. While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Pilot studies found associations between those COMT genotypes and CSA-AKI. Methods. We prospectively included 1741 patients undergoing elective cardiac surgery using cardiopulmonary bypass (CPB). Patients were genotyped for COMT-Val158Met-(G/A) polymorphism (rs4680). Results. Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between COMT genotypes and the RIFLE criteria could be detected. A multiple linear regression analysis for postoperative creatinine increase revealed highly significant associations for aortic cross-clamp time (P<0.001), CPB time (P<0.001), norepinephrine (P<0.001), and age (P<0.001). No associations were found for COMT genotypes or baseline creatinine. With an R2=0.39 and a sample size of 1741, the observed power of the regression analysis was >99%. Conclusions. Based on our results, we can rule out an association between the COMT-Val158Met-(G/A) polymorphism and the appearance of CSA-AKI.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - genetics</subject><subject>Aged</subject><subject>Amino Acid Substitution</subject><subject>Cardiopulmonary Bypass</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Heart Diseases - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - genetics</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNpVkU1Lw0AQhhdRbK2evMuehdj9yu7mIkiwWmytaPVo2GQ37dZ8lE2i5N-bUq31MMzAPPMc5gXgHKMrjH1_SBCmQyICxPgB6GMpfE9yig5BHxEhPUQY6oGTqlohhEnAgmPQIwxzQX3RB-_hbDr33lSGfTk1tfdUZm1euvXSVjkcV_CxrKGCz7b6gCOV1KWDaVc3SVMb-GB1YVo4LlaNa6FKa-NgqJy2KoEvjVsY156Co1RllTn76QPwOrqdh_feZHY3Dm8mnqEc157RPk-CWBBNusFPhZSEy9T4MdGaq1hqmmDGMSeIUqY06zYcG8oMoQkhCR2A66133cS50YkpaqeyaO1srlwblcpG_zeFXUaL8jOiQrCA005wsS_YXf5-qgMut8DSFlp92R2BUbSJIdrEEG1j-LOZDjGp2oMpxgGl3-VQgSo</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Boehm, Johannes</creator><creator>Krane, M.</creator><creator>Wagenpfeil, Stefan</creator><creator>Lahm, H.</creator><creator>Eichhorn, S.</creator><creator>Deutsch, Marcus-André</creator><creator>Kornek, Matthias</creator><creator>Lange, R.</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9202-9737</orcidid><orcidid>https://orcid.org/0000-0002-6845-2332</orcidid><orcidid>https://orcid.org/0000-0003-1369-6425</orcidid><orcidid>https://orcid.org/0000-0002-9128-2220</orcidid></search><sort><creationdate>20130101</creationdate><title>COMT-Val158Met-Polymorphism Is Not a Risk Factor for Acute Kidney Injury after Cardiac Surgery</title><author>Boehm, Johannes ; Krane, M. ; Wagenpfeil, Stefan ; Lahm, H. ; Eichhorn, S. ; Deutsch, Marcus-André ; Kornek, Matthias ; Lange, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e361t-ed56c9b72d256c5f788268fe5b2dd6ab8d3c1461620334ad4e5b61e34e23c22c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - genetics</topic><topic>Aged</topic><topic>Amino Acid Substitution</topic><topic>Cardiopulmonary Bypass</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Heart Diseases - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - genetics</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boehm, Johannes</creatorcontrib><creatorcontrib>Krane, M.</creatorcontrib><creatorcontrib>Wagenpfeil, Stefan</creatorcontrib><creatorcontrib>Lahm, H.</creatorcontrib><creatorcontrib>Eichhorn, S.</creatorcontrib><creatorcontrib>Deutsch, Marcus-André</creatorcontrib><creatorcontrib>Kornek, Matthias</creatorcontrib><creatorcontrib>Lange, R.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boehm, Johannes</au><au>Krane, M.</au><au>Wagenpfeil, Stefan</au><au>Lahm, H.</au><au>Eichhorn, S.</au><au>Deutsch, Marcus-André</au><au>Kornek, Matthias</au><au>Lange, R.</au><au>Chaudhry, Kishore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMT-Val158Met-Polymorphism Is Not a Risk Factor for Acute Kidney Injury after Cardiac Surgery</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background. Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB). Objective. CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to be causal for CSA-AKI. While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Pilot studies found associations between those COMT genotypes and CSA-AKI. Methods. We prospectively included 1741 patients undergoing elective cardiac surgery using cardiopulmonary bypass (CPB). Patients were genotyped for COMT-Val158Met-(G/A) polymorphism (rs4680). Results. Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between COMT genotypes and the RIFLE criteria could be detected. A multiple linear regression analysis for postoperative creatinine increase revealed highly significant associations for aortic cross-clamp time (P<0.001), CPB time (P<0.001), norepinephrine (P<0.001), and age (P<0.001). No associations were found for COMT genotypes or baseline creatinine. With an R2=0.39 and a sample size of 1741, the observed power of the regression analysis was >99%. Conclusions. Based on our results, we can rule out an association between the COMT-Val158Met-(G/A) polymorphism and the appearance of CSA-AKI.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24167357</pmid><doi>10.1155/2013/279046</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9202-9737</orcidid><orcidid>https://orcid.org/0000-0002-6845-2332</orcidid><orcidid>https://orcid.org/0000-0003-1369-6425</orcidid><orcidid>https://orcid.org/0000-0002-9128-2220</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - blood Acute Kidney Injury - genetics Aged Amino Acid Substitution Cardiopulmonary Bypass Catechol O-Methyltransferase - genetics Creatinine - blood Female Genetic Association Studies Heart Diseases - surgery Humans Male Middle Aged Polymorphism, Single Nucleotide Postoperative Complications - blood Postoperative Complications - genetics Prospective Studies Risk Factors |
| title | COMT-Val158Met-Polymorphism Is Not a Risk Factor for Acute Kidney Injury after Cardiac Surgery |
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