Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors
Review of the latest discoveries on the function of Rab27 GTPases and their effectors in neutrophil function, compared to their functions in other leukocytes. The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK ce...
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| Veröffentlicht in: | Journal of leukocyte biology 2013-10, Vol.94 (4), p.613-622 |
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| container_title | Journal of leukocyte biology |
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| creator | Catz, Sergio Daniel |
| description | Review of the latest discoveries on the function of Rab27 GTPases and their effectors in neutrophil function, compared to their functions in other leukocytes.
The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell‐specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. This review focuses on the latest discoveries on the function of Rab27 GTPases and their effectors Munc13‐4 and Slp1 in neutrophil function comparatively to their functions in other leukocytes. |
| doi_str_mv | 10.1189/jlb.1112600 |
| format | Article |
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The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell‐specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. 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The Rab27 family of GTPases regulates the efficiency and specificity of exocytosis in hematopoietic cells, including neutrophils, CTLs, NK cells, and mast cells. However, the mechanisms regulated by Rab27 GTPases are cell‐specific, as they depend on the differential expression and function of particular effector molecules that are recruited by the GTPases. In addition, Rab27 GTPases participate in multiple steps of the regulation of the secretory process, including priming, tethering, docking, and fusion through sequential interaction with multiple effector molecules. Finally, recent reports suggest that Rab27 GTPases and their effectors regulate vesicular trafficking mechanisms other than exocytosis, including endocytosis and phagocytosis. This review focuses on the latest discoveries on the function of Rab27 GTPases and their effectors Munc13‐4 and Slp1 in neutrophil function comparatively to their functions in other leukocytes.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>23378593</pmid><doi>10.1189/jlb.1112600</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of leukocyte biology, 2013-10, Vol.94 (4), p.613-622 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals exocytosis, phagocytosis Humans Immunologic Deficiency Syndromes - enzymology Immunologic Deficiency Syndromes - pathology inflammation Inflammation - enzymology Inflammation - pathology innate immunity Leukocytes - metabolism Munc13‐4 Protein Transport rab GTP-Binding Proteins - metabolism Reviews synaptotagmin‐like protein Transport Vesicles - metabolism |
| title | Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors |
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