Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1

Inhibitors of acyl CoA:cholesterol acyltransferase (ACAT) have attracted considerable interest as a potential treatment for atherosclerosis. Currently available inhibitors probably act nonselectively against the two known ACATs. One of these enzymes, ACAT1, is highly expressed in macrophages in athe...

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Veröffentlicht in:	The Journal of clinical investigation 2000-03, Vol.105 (6), p.711-719
Hauptverfasser:	Accad, M, Smith, S J, Newland, D L, Sanan, D A, King, Jr, L E, Linton, M F, Fazio, S, Farese, Jr, R V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Apolipoproteins E - deficiency Apolipoproteins E - genetics Apolipoproteins E - physiology Arteriosclerosis - enzymology Arteriosclerosis - etiology Arteriosclerosis - genetics Arteriosclerosis - pathology Bone Marrow Transplantation Cholesterol - metabolism Crosses, Genetic Diet, Atherogenic Foam Cells - enzymology Foam Cells - pathology Hypercholesterolemia - complications Hypercholesterolemia - enzymology Hypercholesterolemia - genetics Hypercholesterolemia - pathology Isoenzymes - deficiency Isoenzymes - genetics Isoenzymes - physiology Macrophages - enzymology Mice Mice, Inbred C57BL Mice, Knockout Receptors, LDL - deficiency Receptors, LDL - genetics Receptors, LDL - physiology Skin - enzymology Skin - pathology Sterol O-Acyltransferase - deficiency Sterol O-Acyltransferase - genetics Sterol O-Acyltransferase - physiology Xanthomatosis - enzymology Xanthomatosis - etiology Xanthomatosis - genetics Xanthomatosis - pathology
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