Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

Type 2 diabetes is characterized by abnormalities of insulin action in muscle, adipose tissue, and liver and by altered beta-cell function. To analyze the role of the insulin signaling pathway in these processes, we have generated mice with combined heterozygous null mutations in insulin receptor (i...

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Veröffentlicht in:The Journal of clinical investigation 2000-01, Vol.105 (2), p.199-205
Hauptverfasser: Kido, Y, Burks, D J, Withers, D, Bruning, J C, Kahn, C R, White, M F, Accili, D
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Sprache:eng
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