A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events

Prestin is the motor protein within the lateral membrane of outer hair cells (OHCs), and it is required for mammalian cochlear amplification. Expression of prestin precedes the onset of hearing in mice, and it has been suggested that prestin undergoes a functional maturation within the membrane coin...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2010-10, Vol.299 (4), p.C828-C835
Hauptverfasser:	Bian, Shumin, Koo, Bon W, Kelleher, Stephen, Santos-Sacchi, Joseph, Navaratnam, Dhasakumar S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Membrane - metabolism Cell Membrane - ultrastructure Cells Cochlea - cytology Cochlea - growth & development Cochlea - metabolism Ears & hearing Electric Capacitance Hair Cells, Auditory, Outer - cytology Hair Cells, Auditory, Outer - physiology Humans Immunohistochemistry Ion Channel Gating - physiology Maturation Membrane Transporters, Ion Channels and Pumps Membranes Mice Molecular Motor Proteins - chemistry Molecular Motor Proteins - genetics Molecular Motor Proteins - metabolism Patch-Clamp Techniques Protein Conformation Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Rodents
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