Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication
It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important rol...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-7 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7 |
|---|---|
| container_issue | 2013 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2013 |
| creator | Chen, Yen-Hsu Yang, Kuender D Liu, Jien-Wei Huang, Chung-Hao Liu, Chiung-Fen Chen, Chang-Mei Wang, Lin Yang, Zih-Syuan Chen, Rong-Fu Hsieh, Ching-Jung Lee, Ing-Kit Lin, Chun-Yu |
| description | It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopathogenesis of DHF in studies involving general population. To better understand the relationship between these epidemiological and immunological findings, we performed an in vitro study evaluating the sequential immunological reactions and viral load in the DENV infected mononuclear cells of adults with type 2 DM (T2DM group, n=33) and normal adults (control group, n=29). We found in the T2DM group significantly higher IL-4 level on the first (P=0.049) and the third (P=0.022) postinfection days, while higher IL-10 (P=0.042) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (P=0.009) were detected on the third postinfection day. No significant difference in DENV viral load between the cultured mononuclear cells from both groups was found on the first and third post-infection days. These data immunologically suggest that patients with T2DM are at higher risk for development of DHF/severe dengue and strengthen the previously epidemiologically identified role of DM being a predictive risk factor for progressing into DHF/severe dengue in DENV-affected patients. |
| doi_str_mv | 10.1155/2013/965853 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3773921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1443403476</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-79fba1f8c93f2d4ad75fb9d2f28106dec98923096267890622b1af18f8ce82f23</originalsourceid><addsrcrecordid>eNqNkstuEzEUhkcIRKvSFXvkJYIM9S1z2SChlJZIDSBR2I48nuPE4NjBF6rseI2-XsWD4FFKaHf1xrb8nf_8x-cUxXOC3xAynZ5QTNhJW02bKXtUHFJGeFkRTh7vz4wdFMchfMd5NaTCbfW0OKAc103L8GHxZ26lBxFgQJ-9G5KM2lnkFJrbCN5A-qFtySf3rgRPkLADOvfCJuPkNkK5ENK7zUosAc2ccXZbfol6nYyI2i7RmZDRedRv0eV2A4iiUy16iBBufl-jhbPOJmlAeDQDY0JOpkDGbOlKxxU6BbtMgL5pn8IE9Smijy6i_76zNS9kDszZ_IgJgxbJRL0xWoqxnmfFEyVMgOPb_aj4evb-cvahvPh0Pp-9uyglr2ks61b1gqhGtkzRgYuhnqq-HaiiDcHVALJtWsryD9Iq_x6uKO2JUKTJEdBkih0Vb3e6m9SvYZAwOjPdxuu18NvOCd3df7F61S3dr47VNWspyQIvbwW8-5kgxG6tw1iasOBS6AjnjGPG6-pBKKua3PCMvt6huUUheFB7RwR34xR14xR1uynK9Iu7RezZfzOTgVc7YKXtIK70w9QgI6DEHZhlmLO_Y7XeSA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443368609</pqid></control><display><type>article</type><title>Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Chen, Yen-Hsu ; Yang, Kuender D ; Liu, Jien-Wei ; Huang, Chung-Hao ; Liu, Chiung-Fen ; Chen, Chang-Mei ; Wang, Lin ; Yang, Zih-Syuan ; Chen, Rong-Fu ; Hsieh, Ching-Jung ; Lee, Ing-Kit ; Lin, Chun-Yu</creator><contributor>Bagnarelli, Patrizia</contributor><creatorcontrib>Chen, Yen-Hsu ; Yang, Kuender D ; Liu, Jien-Wei ; Huang, Chung-Hao ; Liu, Chiung-Fen ; Chen, Chang-Mei ; Wang, Lin ; Yang, Zih-Syuan ; Chen, Rong-Fu ; Hsieh, Ching-Jung ; Lee, Ing-Kit ; Lin, Chun-Yu ; Bagnarelli, Patrizia</creatorcontrib><description>It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopathogenesis of DHF in studies involving general population. To better understand the relationship between these epidemiological and immunological findings, we performed an in vitro study evaluating the sequential immunological reactions and viral load in the DENV infected mononuclear cells of adults with type 2 DM (T2DM group, n=33) and normal adults (control group, n=29). We found in the T2DM group significantly higher IL-4 level on the first (P=0.049) and the third (P=0.022) postinfection days, while higher IL-10 (P=0.042) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (P=0.009) were detected on the third postinfection day. No significant difference in DENV viral load between the cultured mononuclear cells from both groups was found on the first and third post-infection days. These data immunologically suggest that patients with T2DM are at higher risk for development of DHF/severe dengue and strengthen the previously epidemiologically identified role of DM being a predictive risk factor for progressing into DHF/severe dengue in DENV-affected patients.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/965853</identifier><identifier>PMID: 24078930</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Case-Control Studies ; Chemokine CCL2 - metabolism ; Clinical Study ; Demography ; Dengue - complications ; Dengue - virology ; Dengue virus ; Dengue Virus - physiology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - virology ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis ; Humans ; Interleukin-10 - biosynthesis ; Interleukin-4 - biosynthesis ; Intracellular Space - virology ; Leukocytes, Mononuclear - virology ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha - metabolism ; Viral Load ; Virus Replication - physiology</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-7</ispartof><rights>Copyright © 2013 Ing-Kit Lee et al.</rights><rights>Copyright © 2013 Ing-Kit Lee et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-79fba1f8c93f2d4ad75fb9d2f28106dec98923096267890622b1af18f8ce82f23</citedby><cites>FETCH-LOGICAL-c472t-79fba1f8c93f2d4ad75fb9d2f28106dec98923096267890622b1af18f8ce82f23</cites><orcidid>0000-0001-9950-9269 ; 0000-0001-5640-4969 ; 0000-0001-6061-6964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773921/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773921/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24078930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bagnarelli, Patrizia</contributor><creatorcontrib>Chen, Yen-Hsu</creatorcontrib><creatorcontrib>Yang, Kuender D</creatorcontrib><creatorcontrib>Liu, Jien-Wei</creatorcontrib><creatorcontrib>Huang, Chung-Hao</creatorcontrib><creatorcontrib>Liu, Chiung-Fen</creatorcontrib><creatorcontrib>Chen, Chang-Mei</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Yang, Zih-Syuan</creatorcontrib><creatorcontrib>Chen, Rong-Fu</creatorcontrib><creatorcontrib>Hsieh, Ching-Jung</creatorcontrib><creatorcontrib>Lee, Ing-Kit</creatorcontrib><creatorcontrib>Lin, Chun-Yu</creatorcontrib><title>Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopathogenesis of DHF in studies involving general population. To better understand the relationship between these epidemiological and immunological findings, we performed an in vitro study evaluating the sequential immunological reactions and viral load in the DENV infected mononuclear cells of adults with type 2 DM (T2DM group, n=33) and normal adults (control group, n=29). We found in the T2DM group significantly higher IL-4 level on the first (P=0.049) and the third (P=0.022) postinfection days, while higher IL-10 (P=0.042) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (P=0.009) were detected on the third postinfection day. No significant difference in DENV viral load between the cultured mononuclear cells from both groups was found on the first and third post-infection days. These data immunologically suggest that patients with T2DM are at higher risk for development of DHF/severe dengue and strengthen the previously epidemiologically identified role of DM being a predictive risk factor for progressing into DHF/severe dengue in DENV-affected patients.</description><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - metabolism</subject><subject>Clinical Study</subject><subject>Demography</subject><subject>Dengue - complications</subject><subject>Dengue - virology</subject><subject>Dengue virus</subject><subject>Dengue Virus - physiology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - virology</subject><subject>Female</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis</subject><subject>Humans</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Intracellular Space - virology</subject><subject>Leukocytes, Mononuclear - virology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Viral Load</subject><subject>Virus Replication - physiology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkstuEzEUhkcIRKvSFXvkJYIM9S1z2SChlJZIDSBR2I48nuPE4NjBF6rseI2-XsWD4FFKaHf1xrb8nf_8x-cUxXOC3xAynZ5QTNhJW02bKXtUHFJGeFkRTh7vz4wdFMchfMd5NaTCbfW0OKAc103L8GHxZ26lBxFgQJ-9G5KM2lnkFJrbCN5A-qFtySf3rgRPkLADOvfCJuPkNkK5ENK7zUosAc2ccXZbfol6nYyI2i7RmZDRedRv0eV2A4iiUy16iBBufl-jhbPOJmlAeDQDY0JOpkDGbOlKxxU6BbtMgL5pn8IE9Smijy6i_76zNS9kDszZ_IgJgxbJRL0xWoqxnmfFEyVMgOPb_aj4evb-cvahvPh0Pp-9uyglr2ks61b1gqhGtkzRgYuhnqq-HaiiDcHVALJtWsryD9Iq_x6uKO2JUKTJEdBkih0Vb3e6m9SvYZAwOjPdxuu18NvOCd3df7F61S3dr47VNWspyQIvbwW8-5kgxG6tw1iasOBS6AjnjGPG6-pBKKua3PCMvt6huUUheFB7RwR34xR14xR1uynK9Iu7RezZfzOTgVc7YKXtIK70w9QgI6DEHZhlmLO_Y7XeSA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Chen, Yen-Hsu</creator><creator>Yang, Kuender D</creator><creator>Liu, Jien-Wei</creator><creator>Huang, Chung-Hao</creator><creator>Liu, Chiung-Fen</creator><creator>Chen, Chang-Mei</creator><creator>Wang, Lin</creator><creator>Yang, Zih-Syuan</creator><creator>Chen, Rong-Fu</creator><creator>Hsieh, Ching-Jung</creator><creator>Lee, Ing-Kit</creator><creator>Lin, Chun-Yu</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9950-9269</orcidid><orcidid>https://orcid.org/0000-0001-5640-4969</orcidid><orcidid>https://orcid.org/0000-0001-6061-6964</orcidid></search><sort><creationdate>20130101</creationdate><title>Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication</title><author>Chen, Yen-Hsu ; Yang, Kuender D ; Liu, Jien-Wei ; Huang, Chung-Hao ; Liu, Chiung-Fen ; Chen, Chang-Mei ; Wang, Lin ; Yang, Zih-Syuan ; Chen, Rong-Fu ; Hsieh, Ching-Jung ; Lee, Ing-Kit ; Lin, Chun-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-79fba1f8c93f2d4ad75fb9d2f28106dec98923096267890622b1af18f8ce82f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - metabolism</topic><topic>Clinical Study</topic><topic>Demography</topic><topic>Dengue - complications</topic><topic>Dengue - virology</topic><topic>Dengue virus</topic><topic>Dengue Virus - physiology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - virology</topic><topic>Female</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis</topic><topic>Humans</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Intracellular Space - virology</topic><topic>Leukocytes, Mononuclear - virology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Viral Load</topic><topic>Virus Replication - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yen-Hsu</creatorcontrib><creatorcontrib>Yang, Kuender D</creatorcontrib><creatorcontrib>Liu, Jien-Wei</creatorcontrib><creatorcontrib>Huang, Chung-Hao</creatorcontrib><creatorcontrib>Liu, Chiung-Fen</creatorcontrib><creatorcontrib>Chen, Chang-Mei</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Yang, Zih-Syuan</creatorcontrib><creatorcontrib>Chen, Rong-Fu</creatorcontrib><creatorcontrib>Hsieh, Ching-Jung</creatorcontrib><creatorcontrib>Lee, Ing-Kit</creatorcontrib><creatorcontrib>Lin, Chun-Yu</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yen-Hsu</au><au>Yang, Kuender D</au><au>Liu, Jien-Wei</au><au>Huang, Chung-Hao</au><au>Liu, Chiung-Fen</au><au>Chen, Chang-Mei</au><au>Wang, Lin</au><au>Yang, Zih-Syuan</au><au>Chen, Rong-Fu</au><au>Hsieh, Ching-Jung</au><au>Lee, Ing-Kit</au><au>Lin, Chun-Yu</au><au>Bagnarelli, Patrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopathogenesis of DHF in studies involving general population. To better understand the relationship between these epidemiological and immunological findings, we performed an in vitro study evaluating the sequential immunological reactions and viral load in the DENV infected mononuclear cells of adults with type 2 DM (T2DM group, n=33) and normal adults (control group, n=29). We found in the T2DM group significantly higher IL-4 level on the first (P=0.049) and the third (P=0.022) postinfection days, while higher IL-10 (P=0.042) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (P=0.009) were detected on the third postinfection day. No significant difference in DENV viral load between the cultured mononuclear cells from both groups was found on the first and third post-infection days. These data immunologically suggest that patients with T2DM are at higher risk for development of DHF/severe dengue and strengthen the previously epidemiologically identified role of DM being a predictive risk factor for progressing into DHF/severe dengue in DENV-affected patients.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24078930</pmid><doi>10.1155/2013/965853</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9950-9269</orcidid><orcidid>https://orcid.org/0000-0001-5640-4969</orcidid><orcidid>https://orcid.org/0000-0001-6061-6964</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2013-01, Vol.2013 (2013), p.1-7 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3773921 |
| source | MEDLINE; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Case-Control Studies Chemokine CCL2 - metabolism Clinical Study Demography Dengue - complications Dengue - virology Dengue virus Dengue Virus - physiology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - virology Female Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Humans Interleukin-10 - biosynthesis Interleukin-4 - biosynthesis Intracellular Space - virology Leukocytes, Mononuclear - virology Male Middle Aged Tumor Necrosis Factor-alpha - metabolism Viral Load Virus Replication - physiology |
| title | Increased Production of Interleukin-4, Interleukin-10, and Granulocyte-Macrophage Colony-Stimulating Factor by Type 2 Diabetes’ Mononuclear Cells Infected with Dengue Virus, but Not Increased Intracellular Viral Multiplication |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T22%3A40%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Production%20of%20Interleukin-4,%20Interleukin-10,%20and%20Granulocyte-Macrophage%20Colony-Stimulating%20Factor%20by%20Type%202%20Diabetes%E2%80%99%20Mononuclear%20Cells%20Infected%20with%20Dengue%20Virus,%20but%20Not%20Increased%20Intracellular%20Viral%20Multiplication&rft.jtitle=BioMed%20research%20international&rft.au=Chen,%20Yen-Hsu&rft.date=2013-01-01&rft.volume=2013&rft.issue=2013&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2013/965853&rft_dat=%3Cproquest_pubme%3E1443403476%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443368609&rft_id=info:pmid/24078930&rfr_iscdi=true |