Increased Hippocampal Neurogenesis and p21 Expression in Depression: Dependent on Antidepressants, Sex, Age, and Antipsychotic Exposure

The mammalian hippocampus continues to generate new neurons throughout life. The function of adult-generated neurons remains controversial, but adult neurogenesis in the hippocampus is related to depression. Studies show that neurogenesis in the hippocampus is regulated by antidepressants in both hu...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2013-10, Vol.38 (11), p.2297-2306
Hauptverfasser:	EPP, Jonathan R, BEASLEY, Clare L, GALEA, Liisa Am
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Age Age Factors Antidepressants Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Antigens, Nuclear - metabolism Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Antipsychotics Biological and medical sciences Cell cycle Cell growth Cyclin-Dependent Kinase Inhibitor p21 - metabolism Depression Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Female Gender differences Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Humans Male Medical sciences Mental depression Microtubule-Associated Proteins - metabolism Middle Aged Mood disorders Nerve Tissue Proteins - metabolism Neurogenesis Neurogenesis - drug effects Neurogenesis - physiology Neurons Neuropeptides - metabolism Neuropharmacology Neurosciences Original Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychosis Psychotropic drugs Sex Characteristics
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