Decreased left perisylvian GABA concentration in children with autism and unaffected siblings

Imbalanced levels of excitation and inhibition (E/I) have been proposed to account for various behavioral and electrophysiological phenotypes in autism. Although proton magnetic resonance spectroscopy (1H-MRS) studies have been published on various metabolite levels in autism, including glutamate, t...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2014-02, Vol.86, p.28-34
Hauptverfasser:	Rojas, Donald C., Singel, Debra, Steinmetz, Sarah, Hepburn, Susan, Brown, Mark S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Auditory cortex Auditory Cortex - metabolism Autism Behavior Child Child Development Disorders, Pervasive - metabolism Consent Creatine Female GABA gamma-Aminobutyric Acid - metabolism Genotype & phenotype Humans J-editing Magnetic Resonance Spectroscopy - methods Male MEGA-PRESS Questionnaires Siblings Spectroscopy Studies Tissue Distribution
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