Characterization of MYC-Induced Tumorigenesis by in Situ Lipid Profiling

We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach of combining DESI-MSI wit...

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Veröffentlicht in:	Analytical chemistry (Washington) 2013-05, Vol.85 (9), p.4259-4262
Hauptverfasser:	Perry, Richard H, Bellovin, David I, Shroff, Emelyn H, Ismail, Ali I, Zabuawala, Tahera, Felsher, Dean W, Zare, Richard N
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Carcinogenesis - genetics Carcinogenesis - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Disease Models, Animal Lipid Metabolism - genetics Lipids Lipids - genetics Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Mass spectrometry Mice Mice, Transgenic Molecules Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Spectrometry, Mass, Electrospray Ionization Transgenic animals
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