Causes and Consequences of Cysteine S-Glutathionylation

Post-translational S-glutathionylation occurs through the reversible addition of a proximal donor of glutathione to thiolate anions of cysteines in target proteins, where the modification alters molecular mass, charge, and structure/function and/or prevents degradation from sulfhydryl overoxidation...

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Veröffentlicht in:	The Journal of biological chemistry 2013-09, Vol.288 (37), p.26497-26504
Hauptverfasser:	Grek, Christina L., Zhang, Jie, Manevich, Yefim, Townsend, Danyelle M., Tew, Kenneth D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cysteine - metabolism Cysteine-mediated Cross-linking Gene Expression Regulation, Enzymologic Glutaredoxins - metabolism Glutathione Glutathione - metabolism Glutathione S-Transferase Glutathione Transferase - metabolism Glutathionylation Humans Kinase Signaling Minireviews Nitric Oxide Nitric Oxide - metabolism Nitrogen - metabolism Nitrosylation Oxidation-Reduction Oxidative Stress Peroxidases Peroxidases - metabolism Peroxiredoxin Protein Processing, Post-Translational Reactive Oxygen Species - metabolism Serpin Serpins - metabolism Sulfhydryl Compounds - metabolism
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