Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics
Recent genome-wide studies conducted in European Whites have identified novel susceptibility genes for childhood acute lymphoblastic leukemia (ALL). We sought to examine whether these loci are susceptibility genes among Hispanics, whose reported incidence of childhood ALL is the highest of all ethni...
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| Veröffentlicht in: | Cancer causes & control 2013-10, Vol.24 (10), p.1789-1795 |
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| creator | Chokkalingam, Anand P. Hsu, Ling-I Metayer, Catherine Hansen, Helen M. Month, Stacy R. Barcellos, Lisa F. Wiemels, Joseph L. Buffler, Patricia A. |
| description | Recent genome-wide studies conducted in European Whites have identified novel susceptibility genes for childhood acute lymphoblastic leukemia (ALL). We sought to examine whether these loci are susceptibility genes among Hispanics, whose reported incidence of childhood ALL is the highest of all ethnic groups in California, and whether their effects differ between Hispanics and non-Hispanic Whites (NHWs). We genotyped 13 variants in these genes among 706 Hispanic (300 cases, 406 controls) and 594 NHW (225 cases, 369 controls) participants in a matched population-based case-control study in California. We found significant associations for the five studied ARID5B variants in both Hispanics (p values of 1.0 × 10⁻⁹ to 0.004) and NHWs (p values of 2.2 × 10⁻⁶ to 0.018). Risk estimates were in the same direction in both groups (ORs of 1.53–1.99 and 1.37–1.84, respectively) and strengthened when restricted to B-cell precursor high-hyperdiploid ALL (>50 chromosomes; ORs of 2.21–3.22 and 1.67–2.71, respectively). Similar results were observed for the single CEBPE variant. Hispanics and NHWs exhibited different susceptibility loci at CDKN2A. Although IKZF1 loci showed significant susceptibility effects among NHWs (p < 1 × 10⁻⁵), their effects among Hispanics were in the same direction but nonsignificant, despite similar minor allele frequencies. Future studies should examine whether the observed effects vary by environmental, immunological, or lifestyle factors. |
| doi_str_mv | 10.1007/s10552-013-0256-3 |
| format | Article |
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We sought to examine whether these loci are susceptibility genes among Hispanics, whose reported incidence of childhood ALL is the highest of all ethnic groups in California, and whether their effects differ between Hispanics and non-Hispanic Whites (NHWs). We genotyped 13 variants in these genes among 706 Hispanic (300 cases, 406 controls) and 594 NHW (225 cases, 369 controls) participants in a matched population-based case-control study in California. We found significant associations for the five studied ARID5B variants in both Hispanics (p values of 1.0 × 10⁻⁹ to 0.004) and NHWs (p values of 2.2 × 10⁻⁶ to 0.018). Risk estimates were in the same direction in both groups (ORs of 1.53–1.99 and 1.37–1.84, respectively) and strengthened when restricted to B-cell precursor high-hyperdiploid ALL (>50 chromosomes; ORs of 2.21–3.22 and 1.67–2.71, respectively). Similar results were observed for the single CEBPE variant. Hispanics and NHWs exhibited different susceptibility loci at CDKN2A. Although IKZF1 loci showed significant susceptibility effects among NHWs (p < 1 × 10⁻⁵), their effects among Hispanics were in the same direction but nonsignificant, despite similar minor allele frequencies. Future studies should examine whether the observed effects vary by environmental, immunological, or lifestyle factors.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-013-0256-3</identifier><identifier>PMID: 23836053</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Acute lymphatic leukemia ; B lymphocytes ; Biomedical and Life Sciences ; Biomedicine ; California ; Cancer ; Cancer Research ; Case-Control Studies ; CCAAT-Enhancer-Binding Proteins - genetics ; CCAAT-Enhancer-Binding Proteins - metabolism ; Child ; Child, Preschool ; Childhood ; Children ; Children & youth ; DNA ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Epidemiology ; Ethnicity ; Female ; Gene Frequency ; Genetic loci ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Genomes ; Genotype ; Hematology ; Hispanic Americans - genetics ; Hispanic people ; Hispanics ; Humans ; Leukemia ; Lymphocytic leukemia ; Male ; Minority & ethnic groups ; Oncology ; Original Paper ; Parents & parenting ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - ethnology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Public Health ; Race ; Self report ; Transcription Factors - genetics ; Transcription Factors - metabolism ; White people</subject><ispartof>Cancer causes & control, 2013-10, Vol.24 (10), p.1789-1795</ispartof><rights>The Author(s) 2013</rights><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-88d3f1f76736426f5ff162c2e4524d69713fb657c5179904676622cf8724ca403</citedby><cites>FETCH-LOGICAL-c591t-88d3f1f76736426f5ff162c2e4524d69713fb657c5179904676622cf8724ca403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24717778$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24717778$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,41464,42533,51294,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23836053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chokkalingam, Anand P.</creatorcontrib><creatorcontrib>Hsu, Ling-I</creatorcontrib><creatorcontrib>Metayer, Catherine</creatorcontrib><creatorcontrib>Hansen, Helen M.</creatorcontrib><creatorcontrib>Month, Stacy R.</creatorcontrib><creatorcontrib>Barcellos, Lisa F.</creatorcontrib><creatorcontrib>Wiemels, Joseph L.</creatorcontrib><creatorcontrib>Buffler, Patricia A.</creatorcontrib><title>Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Recent genome-wide studies conducted in European Whites have identified novel susceptibility genes for childhood acute lymphoblastic leukemia (ALL). We sought to examine whether these loci are susceptibility genes among Hispanics, whose reported incidence of childhood ALL is the highest of all ethnic groups in California, and whether their effects differ between Hispanics and non-Hispanic Whites (NHWs). We genotyped 13 variants in these genes among 706 Hispanic (300 cases, 406 controls) and 594 NHW (225 cases, 369 controls) participants in a matched population-based case-control study in California. We found significant associations for the five studied ARID5B variants in both Hispanics (p values of 1.0 × 10⁻⁹ to 0.004) and NHWs (p values of 2.2 × 10⁻⁶ to 0.018). Risk estimates were in the same direction in both groups (ORs of 1.53–1.99 and 1.37–1.84, respectively) and strengthened when restricted to B-cell precursor high-hyperdiploid ALL (>50 chromosomes; ORs of 2.21–3.22 and 1.67–2.71, respectively). Similar results were observed for the single CEBPE variant. Hispanics and NHWs exhibited different susceptibility loci at CDKN2A. Although IKZF1 loci showed significant susceptibility effects among NHWs (p < 1 × 10⁻⁵), their effects among Hispanics were in the same direction but nonsignificant, despite similar minor allele frequencies. Future studies should examine whether the observed effects vary by environmental, immunological, or lifestyle factors.</description><subject>Acute lymphatic leukemia</subject><subject>B lymphocytes</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>California</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>CCAAT-Enhancer-Binding Proteins - genetics</subject><subject>CCAAT-Enhancer-Binding Proteins - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Children & youth</subject><subject>DNA</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Hematology</subject><subject>Hispanic Americans - genetics</subject><subject>Hispanic people</subject><subject>Hispanics</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Lymphocytic leukemia</subject><subject>Male</subject><subject>Minority & ethnic groups</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Parents & parenting</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - ethnology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Public Health</subject><subject>Race</subject><subject>Self report</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>White people</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9vEzEQxS0EoqHlA3AAWeLCZVv_n90LUhpCWykSqAJxtByvt3G0sYO9W6nfHkdb2sKhpznM772Zp4fQO0pOKSFwlimRklWE8oowqSr-As2oBF4BY_IlmpFGQiWZ4EfoTc5bQohUjLxGR4zXXBHJZ-jXhQtu8BbfmuRNGDL2Ac-vr77Ic2xCixfL8-9LbJLDduP7dhNji-erFc5jtm4_-LXv_XCH-2j9QXnp894Eb_MJetWZPru39_MY_fy6_LG4rFbfLq4W81VlZUOHqq5b3tEOFHAlmOpk11HFLHOivN2qBijv1kqClRSahggFSjFmuxqYsEYQfow-T777cb1zrXVhSKbX--R3Jt3paLz-dxP8Rt_EW80BqOCiGHy6N0jx9-jyoHe-ROt7E1wcs6aiUXVNlFQF_fgfuo1jCiVeoTgnUEsmC0UnyqaYc3LdwzOU6ENteqpNl9r0oTbNi-bD0xQPir89FYBNQC6rcOPSk9PPuL6fRNs8xPRoKoACQM3_ABVKqYM</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Chokkalingam, Anand P.</creator><creator>Hsu, Ling-I</creator><creator>Metayer, Catherine</creator><creator>Hansen, Helen M.</creator><creator>Month, Stacy R.</creator><creator>Barcellos, Lisa F.</creator><creator>Wiemels, Joseph L.</creator><creator>Buffler, Patricia A.</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics</title><author>Chokkalingam, Anand P. ; Hsu, Ling-I ; Metayer, Catherine ; Hansen, Helen M. ; Month, Stacy R. ; Barcellos, Lisa F. ; Wiemels, Joseph L. ; Buffler, Patricia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-88d3f1f76736426f5ff162c2e4524d69713fb657c5179904676622cf8724ca403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute lymphatic leukemia</topic><topic>B lymphocytes</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>California</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>CCAAT-Enhancer-Binding Proteins - genetics</topic><topic>CCAAT-Enhancer-Binding Proteins - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Children & youth</topic><topic>DNA</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Epidemiology</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Hematology</topic><topic>Hispanic Americans - genetics</topic><topic>Hispanic people</topic><topic>Hispanics</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Lymphocytic leukemia</topic><topic>Male</topic><topic>Minority & ethnic groups</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Parents & parenting</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - ethnology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Public Health</topic><topic>Race</topic><topic>Self report</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chokkalingam, Anand P.</creatorcontrib><creatorcontrib>Hsu, Ling-I</creatorcontrib><creatorcontrib>Metayer, Catherine</creatorcontrib><creatorcontrib>Hansen, Helen M.</creatorcontrib><creatorcontrib>Month, Stacy R.</creatorcontrib><creatorcontrib>Barcellos, Lisa F.</creatorcontrib><creatorcontrib>Wiemels, Joseph L.</creatorcontrib><creatorcontrib>Buffler, Patricia A.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chokkalingam, Anand P.</au><au>Hsu, Ling-I</au><au>Metayer, Catherine</au><au>Hansen, Helen M.</au><au>Month, Stacy R.</au><au>Barcellos, Lisa F.</au><au>Wiemels, Joseph L.</au><au>Buffler, Patricia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>24</volume><issue>10</issue><spage>1789</spage><epage>1795</epage><pages>1789-1795</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Recent genome-wide studies conducted in European Whites have identified novel susceptibility genes for childhood acute lymphoblastic leukemia (ALL). We sought to examine whether these loci are susceptibility genes among Hispanics, whose reported incidence of childhood ALL is the highest of all ethnic groups in California, and whether their effects differ between Hispanics and non-Hispanic Whites (NHWs). We genotyped 13 variants in these genes among 706 Hispanic (300 cases, 406 controls) and 594 NHW (225 cases, 369 controls) participants in a matched population-based case-control study in California. We found significant associations for the five studied ARID5B variants in both Hispanics (p values of 1.0 × 10⁻⁹ to 0.004) and NHWs (p values of 2.2 × 10⁻⁶ to 0.018). Risk estimates were in the same direction in both groups (ORs of 1.53–1.99 and 1.37–1.84, respectively) and strengthened when restricted to B-cell precursor high-hyperdiploid ALL (>50 chromosomes; ORs of 2.21–3.22 and 1.67–2.71, respectively). Similar results were observed for the single CEBPE variant. Hispanics and NHWs exhibited different susceptibility loci at CDKN2A. Although IKZF1 loci showed significant susceptibility effects among NHWs (p < 1 × 10⁻⁵), their effects among Hispanics were in the same direction but nonsignificant, despite similar minor allele frequencies. Future studies should examine whether the observed effects vary by environmental, immunological, or lifestyle factors.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>23836053</pmid><doi>10.1007/s10552-013-0256-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute lymphatic leukemia B lymphocytes Biomedical and Life Sciences Biomedicine California Cancer Cancer Research Case-Control Studies CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Child Child, Preschool Childhood Children Children & youth DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epidemiology Ethnicity Female Gene Frequency Genetic loci Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Genomes Genotype Hematology Hispanic Americans - genetics Hispanic people Hispanics Humans Leukemia Lymphocytic leukemia Male Minority & ethnic groups Oncology Original Paper Parents & parenting Precursor Cell Lymphoblastic Leukemia-Lymphoma - ethnology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Public Health Race Self report Transcription Factors - genetics Transcription Factors - metabolism White people |
| title | Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics |
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