Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus
Metabolic assessment of a non‐human primate model of metabolic syndrome and obesity requires the necessary biomarkers specific to the species. While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix...
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| Veröffentlicht in: | American journal of primatology 2013-05, Vol.75 (5), p.500-508 |
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| creator | ZIEGLER, TONI E. COLMAN, RICKI J. TARDIF, SUZETTE D. SOSA, MEGAN E. WEGNER, FREDRICK H. WITTWER, DANIEL J. SHRESTHA, HEMANTA |
| description | Metabolic assessment of a non‐human primate model of metabolic syndrome and obesity requires the necessary biomarkers specific to the species. While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix jacchus) has a small blood volume that necessitates using a single blood volume for multiple analyses. The common marmoset holds a great potential as an alternative primate model for the study of human disease but assay methods need to be developed and validated for the biomarkers of metabolic syndrome. Here we report on the adaptation, development, and validation of commercially available immunoassays for common marmoset samples in small volumes. We have performed biological validations for insulin, adiponectin, leptin, and ghrelin to demonstrate the use of these biomarkers in examining metabolic syndrome and other related diseases in the common marmoset. Am. J. Primatol. 75:500‐508, 2013. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ajp.22126 |
| format | Article |
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While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix jacchus) has a small blood volume that necessitates using a single blood volume for multiple analyses. The common marmoset holds a great potential as an alternative primate model for the study of human disease but assay methods need to be developed and validated for the biomarkers of metabolic syndrome. Here we report on the adaptation, development, and validation of commercially available immunoassays for common marmoset samples in small volumes. We have performed biological validations for insulin, adiponectin, leptin, and ghrelin to demonstrate the use of these biomarkers in examining metabolic syndrome and other related diseases in the common marmoset. Am. J. Primatol. 75:500‐508, 2013. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0275-2565</identifier><identifier>EISSN: 1098-2345</identifier><identifier>DOI: 10.1002/ajp.22126</identifier><identifier>PMID: 23447060</identifier><identifier>CODEN: AJPTDU</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>adiponectin ; Adiponectin - blood ; Animals ; Biomarkers ; Blood ; Callithrix - blood ; Callithrix - physiology ; Diseases ; Energy Metabolism - physiology ; Female ; ghrelin ; Ghrelin - blood ; Immunoassay - methods ; Immunoassay - veterinary ; insulin ; Insulin - blood ; leptin ; Leptin - blood ; Male ; marmoset ; metabolic syndrome ; New World monkeys ; Obesity ; Primate behaviour ; Primate biology ; Reproducibility of Results ; Sex Factors</subject><ispartof>American journal of primatology, 2013-05, Vol.75 (5), p.500-508</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5476-d539851a4467e8a1c29c25e368df573494512fbeb9f239bdc0a7b10c402472223</citedby><cites>FETCH-LOGICAL-c5476-d539851a4467e8a1c29c25e368df573494512fbeb9f239bdc0a7b10c402472223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajp.22126$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajp.22126$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23447060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZIEGLER, TONI E.</creatorcontrib><creatorcontrib>COLMAN, RICKI J.</creatorcontrib><creatorcontrib>TARDIF, SUZETTE D.</creatorcontrib><creatorcontrib>SOSA, MEGAN E.</creatorcontrib><creatorcontrib>WEGNER, FREDRICK H.</creatorcontrib><creatorcontrib>WITTWER, DANIEL J.</creatorcontrib><creatorcontrib>SHRESTHA, HEMANTA</creatorcontrib><title>Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus</title><title>American journal of primatology</title><addtitle>Am. J. Primatol</addtitle><description>Metabolic assessment of a non‐human primate model of metabolic syndrome and obesity requires the necessary biomarkers specific to the species. While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix jacchus) has a small blood volume that necessitates using a single blood volume for multiple analyses. The common marmoset holds a great potential as an alternative primate model for the study of human disease but assay methods need to be developed and validated for the biomarkers of metabolic syndrome. Here we report on the adaptation, development, and validation of commercially available immunoassays for common marmoset samples in small volumes. We have performed biological validations for insulin, adiponectin, leptin, and ghrelin to demonstrate the use of these biomarkers in examining metabolic syndrome and other related diseases in the common marmoset. Am. J. Primatol. 75:500‐508, 2013. © 2013 Wiley Periodicals, Inc.</description><subject>adiponectin</subject><subject>Adiponectin - blood</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Callithrix - blood</subject><subject>Callithrix - physiology</subject><subject>Diseases</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>ghrelin</subject><subject>Ghrelin - blood</subject><subject>Immunoassay - methods</subject><subject>Immunoassay - veterinary</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>marmoset</subject><subject>metabolic syndrome</subject><subject>New World monkeys</subject><subject>Obesity</subject><subject>Primate behaviour</subject><subject>Primate biology</subject><subject>Reproducibility of Results</subject><subject>Sex Factors</subject><issn>0275-2565</issn><issn>1098-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhwBdAkbiARFp7_C--IJWFbYvaghCoiIvleB3W2yRe7KS03x63265oJSQunsP7zfPMPISeE7xDMIZds1ztABAQD9CEYFWVQBl_iCYYJC-BC76FnqS0xJgQJvhjtJV1JrHAE3T63p27Nqw61w9FaIpjN5g6tN4Ws7G3gw998c6HzsQzF1Ph-2JYuGIaui4LxyZ2IbnhTTE1beuHRfQXxdJYuxjTU_SoMW1yz27qNvo2-_B1elAefdo_nO4dlZYzKco5p6rixDAmpKsMsaAscEdFNW-4pEwxTqCpXa0aoKqeW2xkTbBlGJgEALqN3q59V2PdubnNa0TT6lX0eeZLHYzXd5XeL_TPcK6plIRClQ1e3RjE8Gt0adCdT9a1reldGJMmlHJMhAD6HyhgUgmlZEZf3kOXYYx9vkSmiKL54Vd_v15TNoaUoms2cxOsr5LVOVl9nWxmX_y96Ia8jTIDu2vgt2_d5b-d9N7Hz7eW5brDp8FdbDpy1lpIKrk-PdnXX8iPg5PZd9CC_gHi2rsj</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>ZIEGLER, TONI E.</creator><creator>COLMAN, RICKI J.</creator><creator>TARDIF, SUZETTE D.</creator><creator>SOSA, MEGAN E.</creator><creator>WEGNER, FREDRICK H.</creator><creator>WITTWER, DANIEL J.</creator><creator>SHRESTHA, HEMANTA</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SN</scope><scope>7TK</scope><scope>8BJ</scope><scope>8FD</scope><scope>C1K</scope><scope>FQK</scope><scope>FR3</scope><scope>JBE</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201305</creationdate><title>Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus</title><author>ZIEGLER, TONI E. ; COLMAN, RICKI J. ; TARDIF, SUZETTE D. ; SOSA, MEGAN E. ; WEGNER, FREDRICK H. ; WITTWER, DANIEL J. ; SHRESTHA, HEMANTA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5476-d539851a4467e8a1c29c25e368df573494512fbeb9f239bdc0a7b10c402472223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>adiponectin</topic><topic>Adiponectin - blood</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Callithrix - blood</topic><topic>Callithrix - physiology</topic><topic>Diseases</topic><topic>Energy Metabolism - physiology</topic><topic>Female</topic><topic>ghrelin</topic><topic>Ghrelin - blood</topic><topic>Immunoassay - methods</topic><topic>Immunoassay - veterinary</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>marmoset</topic><topic>metabolic syndrome</topic><topic>New World monkeys</topic><topic>Obesity</topic><topic>Primate behaviour</topic><topic>Primate biology</topic><topic>Reproducibility of Results</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZIEGLER, TONI E.</creatorcontrib><creatorcontrib>COLMAN, RICKI J.</creatorcontrib><creatorcontrib>TARDIF, SUZETTE D.</creatorcontrib><creatorcontrib>SOSA, MEGAN E.</creatorcontrib><creatorcontrib>WEGNER, FREDRICK H.</creatorcontrib><creatorcontrib>WITTWER, DANIEL J.</creatorcontrib><creatorcontrib>SHRESTHA, HEMANTA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>International Bibliography of the Social Sciences</collection><collection>Engineering Research Database</collection><collection>International Bibliography of the Social Sciences</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZIEGLER, TONI E.</au><au>COLMAN, RICKI J.</au><au>TARDIF, SUZETTE D.</au><au>SOSA, MEGAN E.</au><au>WEGNER, FREDRICK H.</au><au>WITTWER, DANIEL J.</au><au>SHRESTHA, HEMANTA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus</atitle><jtitle>American journal of primatology</jtitle><addtitle>Am. 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We have performed biological validations for insulin, adiponectin, leptin, and ghrelin to demonstrate the use of these biomarkers in examining metabolic syndrome and other related diseases in the common marmoset. Am. J. Primatol. 75:500‐508, 2013. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23447060</pmid><doi>10.1002/ajp.22126</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adiponectin Adiponectin - blood Animals Biomarkers Blood Callithrix - blood Callithrix - physiology Diseases Energy Metabolism - physiology Female ghrelin Ghrelin - blood Immunoassay - methods Immunoassay - veterinary insulin Insulin - blood leptin Leptin - blood Male marmoset metabolic syndrome New World monkeys Obesity Primate behaviour Primate biology Reproducibility of Results Sex Factors |
| title | Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus |
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