Combinatorial Control of Gene Expression
The complexity and diversity of eukaryotic organisms are a feat of nature’s engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental...
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| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-11 |
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| creator | Mehrotra, Sandhya Mehrotra, Rajesh Renganaath, Kaushik Bhattacharjee, Soumya |
| description | The complexity and diversity of eukaryotic organisms are a feat of nature’s engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived and processed by eukaryotes. Hence, at first glance, the cell’s sparse stockpile of controlling factors does not seem remotely adequate to carry out this response. The question as to how eukaryotes sense and respond to environmental cues has no single answer. It is an amalgamation, an interplay between several processes, pathways, and factors—a combinatorial control. A short description of some of the most important elements that operate this entire conglomerate is given in this paper. |
| doi_str_mv | 10.1155/2013/407263 |
| format | Article |
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Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived and processed by eukaryotes. Hence, at first glance, the cell’s sparse stockpile of controlling factors does not seem remotely adequate to carry out this response. The question as to how eukaryotes sense and respond to environmental cues has no single answer. It is an amalgamation, an interplay between several processes, pathways, and factors—a combinatorial control. A short description of some of the most important elements that operate this entire conglomerate is given in this paper.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/407263</identifier><identifier>PMID: 24069600</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Biomedical research ; Deoxyribonucleic acid ; DNA ; DNA methylation ; DNA-Binding Proteins - metabolism ; Enhancer Elements, Genetic - genetics ; Eukaryotes ; Gene expression ; Gene Expression Regulation ; Genetic aspects ; Genomes ; Genomics ; Humans ; Models, Biological ; Physiological aspects ; Proteins ; Review ; RNA, Long Noncoding - metabolism ; Transcription factors ; Transcription Factors - metabolism</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-11</ispartof><rights>Copyright © 2013 Soumya Bhattacharjee et al.</rights><rights>COPYRIGHT 2013 John Wiley & Sons, Inc.</rights><rights>Copyright © 2013 Soumya Bhattacharjee et al. Soumya Bhattacharjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Soumya Bhattacharjee et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-ae2b1d02711a029b877b40bfabf60e0c32579231e0e6c331038f284f2fe2cb713</citedby><cites>FETCH-LOGICAL-c528t-ae2b1d02711a029b877b40bfabf60e0c32579231e0e6c331038f284f2fe2cb713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771257/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771257/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24069600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Iatrou, K.</contributor><creatorcontrib>Mehrotra, Sandhya</creatorcontrib><creatorcontrib>Mehrotra, Rajesh</creatorcontrib><creatorcontrib>Renganaath, Kaushik</creatorcontrib><creatorcontrib>Bhattacharjee, Soumya</creatorcontrib><title>Combinatorial Control of Gene Expression</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The complexity and diversity of eukaryotic organisms are a feat of nature’s engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived and processed by eukaryotes. Hence, at first glance, the cell’s sparse stockpile of controlling factors does not seem remotely adequate to carry out this response. The question as to how eukaryotes sense and respond to environmental cues has no single answer. It is an amalgamation, an interplay between several processes, pathways, and factors—a combinatorial control. A short description of some of the most important elements that operate this entire conglomerate is given in this paper.</description><subject>Animals</subject><subject>Biomedical research</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Enhancer Elements, Genetic - genetics</subject><subject>Eukaryotes</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Review</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rGzEQhkVJqUOaU-_F0EtIcTMaaaXdSyCYNC0EcknPQrse2TJryZXsfPz7aHHipD1FFwn08PDOvIx94fCD86o6Q-DiTIJGJT6wQxRcThSX_GD_FmLEjnNeQjk1V9CoT2yEElSjAA7ZyTSuWh_sJiZv-_E0hk2K_Ti68RUFGl8-rBPl7GP4zD4622c6fr6P2J-fl7fTX5Prm6vf04vrSVdhvZlYwpbPADXnFrBpa61bCa2zrVNA0AmsdFOiEZDqhOAgaoe1dOgIu1ZzccTOd971tl3RrKMSyPZmnfzKpkcTrTf__gS_MPN4Z4TWvMiL4ORZkOLfLeWNWfncUd_bQHGbDZeyQV1Xqn4HKhpEVdWioN_-Q5dxm0LZxEBJhVA1zSs1tz0ZH1wsEbtBai6EFkKjlgP1fUd1KeacyO2n42CGVs3Qqtm1WuivbxeyZ186LMDpDlj4MLP3_n02Kgg5-wYGiSXjE3FnrzA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Mehrotra, Sandhya</creator><creator>Mehrotra, Rajesh</creator><creator>Renganaath, Kaushik</creator><creator>Bhattacharjee, Soumya</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Combinatorial Control of Gene Expression</title><author>Mehrotra, Sandhya ; Mehrotra, Rajesh ; Renganaath, Kaushik ; Bhattacharjee, Soumya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-ae2b1d02711a029b877b40bfabf60e0c32579231e0e6c331038f284f2fe2cb713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomedical research</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA-Binding Proteins - 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| subjects | Animals Biomedical research Deoxyribonucleic acid DNA DNA methylation DNA-Binding Proteins - metabolism Enhancer Elements, Genetic - genetics Eukaryotes Gene expression Gene Expression Regulation Genetic aspects Genomes Genomics Humans Models, Biological Physiological aspects Proteins Review RNA, Long Noncoding - metabolism Transcription factors Transcription Factors - metabolism |
| title | Combinatorial Control of Gene Expression |
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