Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast

Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to maintain centromeric heterochromatin. However, Sir2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 2013-08, Vol.32 (17), p.2321-2335
Hauptverfasser:	Alper, Benjamin J, Job, Godwin, Yadav, Rajesh K, Shanker, Sreenath, Lowe, Brandon R, Partridge, Janet F
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism centromere Centromere - metabolism Chromatin Assembly and Disassembly EMBO09 Enzymes fission yeast Gene expression heterochromatin Heterochromatin - genetics Heterochromatin - metabolism histone deacetylase histone methyltransferase Histones - metabolism Lysine - metabolism Methyltransferases - genetics Methyltransferases - metabolism Molecular biology Mutation RNA Interference Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Substrate Specificity Telomere - genetics Telomere - metabolism Upstream Yeast Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!