Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye

Abstract Delivery of sufficient amounts of therapeutic drugs into the eye is often a challenging task. In this study, ultrasound application (frequencies of 400 KHz to 1 MHz, intensities of 0.3–1.0 W/cm2 and exposure duration of 5 min) was investigated to overcome the barrier properties of cornea, w...

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Veröffentlicht in:	Ultrasound in medicine & biology 2013-04, Vol.39 (4), p.638-646
Hauptverfasser:	Nabili, Marjan, Patel, Hetal, Mahesh, Sankaranarayana P, Liu, Ji, Geist, Craig, Zderic, Vesna
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Cornea Cornea - metabolism Drug delivery Electrophoresis - methods In Vitro Techniques In vitro Ocular diseases Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - pharmacokinetics Rabbits Radiology Sonication - methods Sonophoresis Therapeutic ultrasound Tissue Distribution
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