Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults : A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial
Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n=57) group or the place...
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| creator | Park, Sunju Nahmkoong, Won Cheon, ChunHoo Park, Jeong-Su Jang, Bo-Hyoung Shin, Yong Cheol Kim, Kyung-Soo Go, Hoyeon Song, Yun-Kyung Ko, Seong-Gyu |
| description | Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n=57) group or the placebo group (n=55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P=0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P |
| doi_str_mv | 10.1155/2013/498935 |
| format | Article |
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The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n=57) group or the placebo group (n=55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P=0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P<0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. Conclusion. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/498935</identifier><identifier>PMID: 24062784</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adults ; Anthropometry ; Blood pressure ; Body fat ; Body weight loss ; Caffeine ; Cardiovascular disease ; Cholesterol ; Clinical trials ; Diabetes ; Double-blind studies ; Evidence-based medicine ; Herbal medicine ; Hospitals ; Hypertension ; Medicine ; Metabolism ; Nutrition research ; Obesity ; Randomization ; Statistical analysis ; Triglycerides ; Weight control ; Weight loss ; Womens health</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-10</ispartof><rights>Copyright © 2013 Sunju Park et al.</rights><rights>Copyright © 2013 Sunju Park et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Sunju Park et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-119aea02aba881e36e3875879923457076ac1b91b4222f44aecc09ab1ea46f053</citedby><cites>FETCH-LOGICAL-c499t-119aea02aba881e36e3875879923457076ac1b91b4222f44aecc09ab1ea46f053</cites><orcidid>0000-0002-6398-4612 ; 0000-0002-2141-3483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770019/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770019/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24062784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yin, Chang Shik</contributor><creatorcontrib>Park, Sunju</creatorcontrib><creatorcontrib>Nahmkoong, Won</creatorcontrib><creatorcontrib>Cheon, ChunHoo</creatorcontrib><creatorcontrib>Park, Jeong-Su</creatorcontrib><creatorcontrib>Jang, Bo-Hyoung</creatorcontrib><creatorcontrib>Shin, Yong Cheol</creatorcontrib><creatorcontrib>Kim, Kyung-Soo</creatorcontrib><creatorcontrib>Go, Hoyeon</creatorcontrib><creatorcontrib>Song, Yun-Kyung</creatorcontrib><creatorcontrib>Ko, Seong-Gyu</creatorcontrib><title>Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults : A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n=57) group or the placebo group (n=55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P=0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P<0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. Conclusion. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.</description><subject>Adults</subject><subject>Anthropometry</subject><subject>Blood pressure</subject><subject>Body fat</subject><subject>Body weight loss</subject><subject>Caffeine</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Diabetes</subject><subject>Double-blind studies</subject><subject>Evidence-based medicine</subject><subject>Herbal medicine</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Randomization</subject><subject>Statistical analysis</subject><subject>Triglycerides</subject><subject>Weight control</subject><subject>Weight 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Sunju</creator><creator>Nahmkoong, Won</creator><creator>Cheon, ChunHoo</creator><creator>Park, Jeong-Su</creator><creator>Jang, Bo-Hyoung</creator><creator>Shin, Yong Cheol</creator><creator>Kim, Kyung-Soo</creator><creator>Go, Hoyeon</creator><creator>Song, Yun-Kyung</creator><creator>Ko, Seong-Gyu</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi 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Shik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults : A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n=57) group or the placebo group (n=55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P=0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P<0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. Conclusion. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24062784</pmid><doi>10.1155/2013/498935</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6398-4612</orcidid><orcidid>https://orcid.org/0000-0002-2141-3483</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-10 |
| issn | 1741-427X 1741-4288 |
| language | eng |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Adults Anthropometry Blood pressure Body fat Body weight loss Caffeine Cardiovascular disease Cholesterol Clinical trials Diabetes Double-blind studies Evidence-based medicine Herbal medicine Hospitals Hypertension Medicine Metabolism Nutrition research Obesity Randomization Statistical analysis Triglycerides Weight control Weight loss Womens health |
| title | Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults : A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial |
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