Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics
Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and o...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2013-04, Vol.340 (6129), p.211-216 |
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| creator | Kim, Tae-il McCall, Jordan G. Jung, Yei Hwan Huang, Xian Siuda, Edward R. Li, Yuhang Song, Jizhou Song, Young Min Pao, Hsuan An Kim, Rak-Hwan Lu, Chaofeng Lee, Sung Dan Song, Il-Sun Shin, Gunchul Al-Hasani, Ream Kim, Stanley Tan, Meng Peun Huang, Yonggang Omenetto, Fiorenzo G. Rogers, John A. Bruchas, Michael R. |
| description | Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomédical science and engineering. |
| doi_str_mv | 10.1126/science.1232437 |
| format | Article |
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In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomédical science and engineering.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1232437</identifier><identifier>PMID: 23580530</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Actuators ; Aerospace engineering ; Animal behavior ; animal models ; Animals ; Behavior, Animal ; Biological ; Brain ; Brain - physiology ; Brain Mapping - instrumentation ; Brain Mapping - methods ; Computer engineering ; Electric Stimulation ; Electrophysiological Phenomena ; ENGINEERING ; Fiber optic cables ; HEK293 Cells ; Humans ; Light emitting diodes ; Materials science ; Mechanical engineering ; Mice ; Microelectrodes ; Miniaturization ; Municipal engineering ; Neurons ; Neurons - physiology ; neurophysiology ; Neurosciences ; Optical engineering ; Optics ; Optoelectronics ; Optogenetics ; Photic Stimulation ; Semiconductor devices ; Semiconductors ; Sensors ; silicon ; Silicon devices ; tissues ; Wireless networks</subject><ispartof>Science (American Association for the Advancement of Science), 2013-04, Vol.340 (6129), p.211-216</ispartof><rights>Copyright © 2013 American Association for the Advancement of Science</rights><rights>Copyright © 2013, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-afc7a8dfbcd643c0d90a631e9130c13bd05cb3690e13094f31f800aa26d50e813</citedby><cites>FETCH-LOGICAL-c536t-afc7a8dfbcd643c0d90a631e9130c13bd05cb3690e13094f31f800aa26d50e813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41942567$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41942567$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23580530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1875506$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Tae-il</creatorcontrib><creatorcontrib>McCall, Jordan G.</creatorcontrib><creatorcontrib>Jung, Yei Hwan</creatorcontrib><creatorcontrib>Huang, Xian</creatorcontrib><creatorcontrib>Siuda, Edward R.</creatorcontrib><creatorcontrib>Li, Yuhang</creatorcontrib><creatorcontrib>Song, Jizhou</creatorcontrib><creatorcontrib>Song, Young Min</creatorcontrib><creatorcontrib>Pao, Hsuan An</creatorcontrib><creatorcontrib>Kim, Rak-Hwan</creatorcontrib><creatorcontrib>Lu, Chaofeng</creatorcontrib><creatorcontrib>Lee, Sung Dan</creatorcontrib><creatorcontrib>Song, Il-Sun</creatorcontrib><creatorcontrib>Shin, Gunchul</creatorcontrib><creatorcontrib>Al-Hasani, Ream</creatorcontrib><creatorcontrib>Kim, Stanley</creatorcontrib><creatorcontrib>Tan, Meng Peun</creatorcontrib><creatorcontrib>Huang, Yonggang</creatorcontrib><creatorcontrib>Omenetto, Fiorenzo G.</creatorcontrib><creatorcontrib>Rogers, John A.</creatorcontrib><creatorcontrib>Bruchas, Michael R.</creatorcontrib><creatorcontrib>Univ. of Illinois at Urbana-Champaign, IL (United States)</creatorcontrib><title>Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomédical science and engineering.</description><subject>Actuators</subject><subject>Aerospace engineering</subject><subject>Animal behavior</subject><subject>animal models</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biological</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Brain Mapping - instrumentation</subject><subject>Brain Mapping - methods</subject><subject>Computer engineering</subject><subject>Electric Stimulation</subject><subject>Electrophysiological Phenomena</subject><subject>ENGINEERING</subject><subject>Fiber optic cables</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>Light emitting diodes</subject><subject>Materials science</subject><subject>Mechanical engineering</subject><subject>Mice</subject><subject>Microelectrodes</subject><subject>Miniaturization</subject><subject>Municipal engineering</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>neurophysiology</subject><subject>Neurosciences</subject><subject>Optical engineering</subject><subject>Optics</subject><subject>Optoelectronics</subject><subject>Optogenetics</subject><subject>Photic Stimulation</subject><subject>Semiconductor devices</subject><subject>Semiconductors</subject><subject>Sensors</subject><subject>silicon</subject><subject>Silicon devices</subject><subject>tissues</subject><subject>Wireless networks</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuPFCEUhYnROG3r2pWmohsX1syFW1DFxmTS8THJJLPwtSQURU3TqYYWKI3_XuxuO-pmViScj8PlcAh5SuGcUiYuknHWG3tOGbIG23tkQUHyWjLA-2QBgKLuoOVn5FFKG4CiSXxIzhjyDjjCgny58htrsu4n-7pa2WmaJx3rj0ZPtrrZ5WCnosbgnUnVD5fX1eVuNzmjsws-VWOI1VcXC5TSHr-13ubCPiYPRj0l--S4Lsnnd28_rT7U1zfvr1aX17XhKHKtR9Pqbhh7M4gGDQwStEBqJUUwFPsBuOlRSLBlQzYj0rED0JqJgYPtKC7Jm4Pvbu63djDW56gntYtuq-NPFbRT_yrerdVt-K6wFVJiVwxeHAxCyk6VOLM1axO8L89WtGs5B1GgV8dbYvg225TV1iVTwtLehjkpVpJF5LRhd6K0g5I8FbK5G0UmWiab8pdL8vI_dBPm6Euye4qxrt2PeXGgTAwpRTuecqCgftdFHeuijnUpJ57_Hd-J_9OPAjw7AJuUQzzpDS1jcdHiLx-Xxdk</recordid><startdate>20130412</startdate><enddate>20130412</enddate><creator>Kim, Tae-il</creator><creator>McCall, Jordan G.</creator><creator>Jung, Yei Hwan</creator><creator>Huang, Xian</creator><creator>Siuda, Edward R.</creator><creator>Li, Yuhang</creator><creator>Song, Jizhou</creator><creator>Song, Young Min</creator><creator>Pao, Hsuan An</creator><creator>Kim, Rak-Hwan</creator><creator>Lu, Chaofeng</creator><creator>Lee, Sung Dan</creator><creator>Song, Il-Sun</creator><creator>Shin, Gunchul</creator><creator>Al-Hasani, Ream</creator><creator>Kim, Stanley</creator><creator>Tan, Meng Peun</creator><creator>Huang, Yonggang</creator><creator>Omenetto, Fiorenzo G.</creator><creator>Rogers, John A.</creator><creator>Bruchas, Michael R.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><general>AAAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>OIOZB</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20130412</creationdate><title>Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics</title><author>Kim, Tae-il ; McCall, Jordan G. ; Jung, Yei Hwan ; Huang, Xian ; Siuda, Edward R. ; Li, Yuhang ; Song, Jizhou ; Song, Young Min ; Pao, Hsuan An ; Kim, Rak-Hwan ; Lu, Chaofeng ; Lee, Sung Dan ; Song, Il-Sun ; Shin, Gunchul ; Al-Hasani, Ream ; Kim, Stanley ; Tan, Meng Peun ; Huang, Yonggang ; Omenetto, Fiorenzo G. ; Rogers, John A. ; Bruchas, Michael R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-afc7a8dfbcd643c0d90a631e9130c13bd05cb3690e13094f31f800aa26d50e813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Actuators</topic><topic>Aerospace engineering</topic><topic>Animal behavior</topic><topic>animal models</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biological</topic><topic>Brain</topic><topic>Brain - 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| ispartof | Science (American Association for the Advancement of Science), 2013-04, Vol.340 (6129), p.211-216 |
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| language | eng |
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| source | American Association for the Advancement of Science; MEDLINE; JSTOR Complete Journals |
| subjects | Actuators Aerospace engineering Animal behavior animal models Animals Behavior, Animal Biological Brain Brain - physiology Brain Mapping - instrumentation Brain Mapping - methods Computer engineering Electric Stimulation Electrophysiological Phenomena ENGINEERING Fiber optic cables HEK293 Cells Humans Light emitting diodes Materials science Mechanical engineering Mice Microelectrodes Miniaturization Municipal engineering Neurons Neurons - physiology neurophysiology Neurosciences Optical engineering Optics Optoelectronics Optogenetics Photic Stimulation Semiconductor devices Semiconductors Sensors silicon Silicon devices tissues Wireless networks |
| title | Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics |
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