Delirium in Older Emergency Department Patients Is an Independent Predictor of Hospital Length of Stay

ACADEMIC EMERGENCY MEDICINE 2011; 18:451–457 © 2011 by the Society for Academic Emergency Medicine Objectives:  The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length...

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Veröffentlicht in:Academic emergency medicine 2011-05, Vol.18 (5), p.451-457
Hauptverfasser: Han, Jin H., Eden, Svetlana, Shintani, Ayumi, Morandi, Alessandro, Schnelle, John, Dittus, Robert S., Storrow, Alan B., Ely, E. Wesley
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container_end_page 457
container_issue 5
container_start_page 451
container_title Academic emergency medicine
container_volume 18
creator Han, Jin H.
Eden, Svetlana
Shintani, Ayumi
Morandi, Alessandro
Schnelle, John
Dittus, Robert S.
Storrow, Alan B.
Ely, E. Wesley
description ACADEMIC EMERGENCY MEDICINE 2011; 18:451–457 © 2011 by the Society for Academic Emergency Medicine Objectives:  The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length of stay (LOS). Methods:  This prospective cohort study was conducted at a tertiary care, academic ED from May 2007 to August 2008. The study included English‐speaking patients aged 65 and older who were in the ED for less than 12 hours at enrollment. Patients were excluded if they refused consent, were previously enrolled, were unable to follow simple commands at baseline, were comatose, or did not have a delirium assessment performed by the research staff. The Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU) was used to determine delirium status. Patients who were discharged directly from the ED were considered to have a hospital LOS of 0 days. To determine if delirium in the ED was independently associated with time to discharge, Cox proportional hazard regression was performed adjusted for age, comorbidity burden, severity of illness, dementia, functional impairment, nursing home residence, and surgical procedure. A sensitivity analysis, which included admitted patients only, was also performed. Results:  A total of 628 patients met enrollment criteria. The median age was 75 years (interquartile range [IQR] = 69–81), 365 (58%) patients were female, 111 (18%) were nonwhite, 351 (56%) were admitted to the hospital, and 108 (17%) were delirious in the ED. Median LOS was 2 days (IQR = 0–5.5) for delirious ED patients and 1 day (IQR = 0–3) for nondelirious ED patients (p 
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Wesley</creator><creatorcontrib>Han, Jin H. ; Eden, Svetlana ; Shintani, Ayumi ; Morandi, Alessandro ; Schnelle, John ; Dittus, Robert S. ; Storrow, Alan B. ; Ely, E. Wesley</creatorcontrib><description>ACADEMIC EMERGENCY MEDICINE 2011; 18:451–457 © 2011 by the Society for Academic Emergency Medicine Objectives:  The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length of stay (LOS). Methods:  This prospective cohort study was conducted at a tertiary care, academic ED from May 2007 to August 2008. The study included English‐speaking patients aged 65 and older who were in the ED for less than 12 hours at enrollment. Patients were excluded if they refused consent, were previously enrolled, were unable to follow simple commands at baseline, were comatose, or did not have a delirium assessment performed by the research staff. The Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU) was used to determine delirium status. Patients who were discharged directly from the ED were considered to have a hospital LOS of 0 days. To determine if delirium in the ED was independently associated with time to discharge, Cox proportional hazard regression was performed adjusted for age, comorbidity burden, severity of illness, dementia, functional impairment, nursing home residence, and surgical procedure. A sensitivity analysis, which included admitted patients only, was also performed. Results:  A total of 628 patients met enrollment criteria. The median age was 75 years (interquartile range [IQR] = 69–81), 365 (58%) patients were female, 111 (18%) were nonwhite, 351 (56%) were admitted to the hospital, and 108 (17%) were delirious in the ED. Median LOS was 2 days (IQR = 0–5.5) for delirious ED patients and 1 day (IQR = 0–3) for nondelirious ED patients (p &lt; 0.001). The hazard ratio (HR) of delirium for time to discharge was 0.71 (95% confidence interval [CI] = 0.57 to 0.89) after adjusting for confounders, and indicated that ED patients with delirium were more likely to have prolonged hospital LOS compared with those without delirium. For the sensitivity analysis, which included only hospitalized patients, the adjusted HR was 0.76 (95% CI = 0.58 to 0.99). Conclusions:  Delirium in older ED patients has negative consequences and is an independent predictor of prolonged hospitalizations.</description><identifier>ISSN: 1069-6563</identifier><identifier>EISSN: 1553-2712</identifier><identifier>DOI: 10.1111/j.1553-2712.2011.01065.x</identifier><identifier>PMID: 21521405</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Academic Medical Centers ; Aged ; Aged, 80 and over ; Delirium ; Delirium - diagnosis ; Delirium - epidemiology ; Delirium - therapy ; Emergency medical care ; Emergency Service, Hospital ; Female ; Geriatric Assessment ; Hospitalization ; Hospitalization - statistics &amp; numerical data ; Humans ; Length of Stay - statistics &amp; numerical data ; Male ; Patients ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Studies</subject><ispartof>Academic emergency medicine, 2011-05, Vol.18 (5), p.451-457</ispartof><rights>2011 by the Society for Academic Emergency Medicine</rights><rights>2011 by the Society for Academic Emergency Medicine.</rights><rights>Copyright Hanley &amp; Belfus, Inc. May 2011</rights><rights>2011 by the Society for Academic Emergency Medicine 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5675-8301bb368b7e606f8d8e8f2c397843e361441483c118b4bcd8f40361f6438f583</citedby><cites>FETCH-LOGICAL-c5675-8301bb368b7e606f8d8e8f2c397843e361441483c118b4bcd8f40361f6438f583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1553-2712.2011.01065.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1553-2712.2011.01065.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21521405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Jin H.</creatorcontrib><creatorcontrib>Eden, Svetlana</creatorcontrib><creatorcontrib>Shintani, Ayumi</creatorcontrib><creatorcontrib>Morandi, Alessandro</creatorcontrib><creatorcontrib>Schnelle, John</creatorcontrib><creatorcontrib>Dittus, Robert S.</creatorcontrib><creatorcontrib>Storrow, Alan B.</creatorcontrib><creatorcontrib>Ely, E. Wesley</creatorcontrib><title>Delirium in Older Emergency Department Patients Is an Independent Predictor of Hospital Length of Stay</title><title>Academic emergency medicine</title><addtitle>Acad Emerg Med</addtitle><description>ACADEMIC EMERGENCY MEDICINE 2011; 18:451–457 © 2011 by the Society for Academic Emergency Medicine Objectives:  The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length of stay (LOS). Methods:  This prospective cohort study was conducted at a tertiary care, academic ED from May 2007 to August 2008. The study included English‐speaking patients aged 65 and older who were in the ED for less than 12 hours at enrollment. Patients were excluded if they refused consent, were previously enrolled, were unable to follow simple commands at baseline, were comatose, or did not have a delirium assessment performed by the research staff. The Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU) was used to determine delirium status. Patients who were discharged directly from the ED were considered to have a hospital LOS of 0 days. To determine if delirium in the ED was independently associated with time to discharge, Cox proportional hazard regression was performed adjusted for age, comorbidity burden, severity of illness, dementia, functional impairment, nursing home residence, and surgical procedure. A sensitivity analysis, which included admitted patients only, was also performed. Results:  A total of 628 patients met enrollment criteria. The median age was 75 years (interquartile range [IQR] = 69–81), 365 (58%) patients were female, 111 (18%) were nonwhite, 351 (56%) were admitted to the hospital, and 108 (17%) were delirious in the ED. Median LOS was 2 days (IQR = 0–5.5) for delirious ED patients and 1 day (IQR = 0–3) for nondelirious ED patients (p &lt; 0.001). The hazard ratio (HR) of delirium for time to discharge was 0.71 (95% confidence interval [CI] = 0.57 to 0.89) after adjusting for confounders, and indicated that ED patients with delirium were more likely to have prolonged hospital LOS compared with those without delirium. For the sensitivity analysis, which included only hospitalized patients, the adjusted HR was 0.76 (95% CI = 0.58 to 0.99). Conclusions:  Delirium in older ED patients has negative consequences and is an independent predictor of prolonged hospitalizations.</description><subject>Academic Medical Centers</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Delirium</subject><subject>Delirium - diagnosis</subject><subject>Delirium - epidemiology</subject><subject>Delirium - therapy</subject><subject>Emergency medical care</subject><subject>Emergency Service, Hospital</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Hospitalization</subject><subject>Hospitalization - statistics &amp; numerical data</subject><subject>Humans</subject><subject>Length of Stay - statistics &amp; numerical data</subject><subject>Male</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Studies</subject><issn>1069-6563</issn><issn>1553-2712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1v1DAQjRAVLYW_gCwunBLs-COTC1K1XehKWxUJOFtOMtl6lTjBTqD773FoWUpP-DAzmnnzNM8vSQijGYvv_T5jUvI0L1ie5ZSxjDKqZHb3LDk7Dp7HmqoyVVLx0-RlCHtKqSzK4kVymjOZM0HlWdJeYme9nXtiHbnpGvRk3aPfoasP5BJH46ce3UQ-m8nGHMgmEOPIxjU4YgzLyGNj62nwZGjJ1RBGO5mObNHtptul9WUyh1fJSWu6gK8f8nny7eP66-oq3d582qwutmktVSFT4JRVFVdQFaioaqEBhDaveVmA4MgVE4IJ4DVjUImqbqAVNHZbJTi0Evh58uGed5yrHps63udNp0dve-MPejBW_ztx9lbvhh-aFwoYp5Hg3QOBH77PGCbd21Bj1xmHwxw0FEKAKnMekW-fIPfD7F1Up0EBxL-GMoLgHlT7IQSP7fEURvVipd7rxTG9OKYXK_VvK_VdXH3zWMpx8Y93f7X-tB0e_ptYX6zW10vJfwEwiqy2</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Han, Jin H.</creator><creator>Eden, Svetlana</creator><creator>Shintani, Ayumi</creator><creator>Morandi, Alessandro</creator><creator>Schnelle, John</creator><creator>Dittus, Robert S.</creator><creator>Storrow, Alan B.</creator><creator>Ely, E. Wesley</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201105</creationdate><title>Delirium in Older Emergency Department Patients Is an Independent Predictor of Hospital Length of Stay</title><author>Han, Jin H. ; Eden, Svetlana ; Shintani, Ayumi ; Morandi, Alessandro ; Schnelle, John ; Dittus, Robert S. ; Storrow, Alan B. ; Ely, E. Wesley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5675-8301bb368b7e606f8d8e8f2c397843e361441483c118b4bcd8f40361f6438f583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Academic Medical Centers</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Delirium</topic><topic>Delirium - diagnosis</topic><topic>Delirium - epidemiology</topic><topic>Delirium - therapy</topic><topic>Emergency medical care</topic><topic>Emergency Service, Hospital</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Hospitalization</topic><topic>Hospitalization - statistics &amp; numerical data</topic><topic>Humans</topic><topic>Length of Stay - statistics &amp; numerical data</topic><topic>Male</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Jin H.</creatorcontrib><creatorcontrib>Eden, Svetlana</creatorcontrib><creatorcontrib>Shintani, Ayumi</creatorcontrib><creatorcontrib>Morandi, Alessandro</creatorcontrib><creatorcontrib>Schnelle, John</creatorcontrib><creatorcontrib>Dittus, Robert S.</creatorcontrib><creatorcontrib>Storrow, Alan B.</creatorcontrib><creatorcontrib>Ely, E. Wesley</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Academic emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jin H.</au><au>Eden, Svetlana</au><au>Shintani, Ayumi</au><au>Morandi, Alessandro</au><au>Schnelle, John</au><au>Dittus, Robert S.</au><au>Storrow, Alan B.</au><au>Ely, E. Wesley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delirium in Older Emergency Department Patients Is an Independent Predictor of Hospital Length of Stay</atitle><jtitle>Academic emergency medicine</jtitle><addtitle>Acad Emerg Med</addtitle><date>2011-05</date><risdate>2011</risdate><volume>18</volume><issue>5</issue><spage>451</spage><epage>457</epage><pages>451-457</pages><issn>1069-6563</issn><eissn>1553-2712</eissn><abstract>ACADEMIC EMERGENCY MEDICINE 2011; 18:451–457 © 2011 by the Society for Academic Emergency Medicine Objectives:  The consequences of delirium in the emergency department (ED) remain unclear. This study sought to determine if delirium in the ED was an independent predictor of prolonged hospital length of stay (LOS). Methods:  This prospective cohort study was conducted at a tertiary care, academic ED from May 2007 to August 2008. The study included English‐speaking patients aged 65 and older who were in the ED for less than 12 hours at enrollment. Patients were excluded if they refused consent, were previously enrolled, were unable to follow simple commands at baseline, were comatose, or did not have a delirium assessment performed by the research staff. The Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU) was used to determine delirium status. Patients who were discharged directly from the ED were considered to have a hospital LOS of 0 days. To determine if delirium in the ED was independently associated with time to discharge, Cox proportional hazard regression was performed adjusted for age, comorbidity burden, severity of illness, dementia, functional impairment, nursing home residence, and surgical procedure. A sensitivity analysis, which included admitted patients only, was also performed. Results:  A total of 628 patients met enrollment criteria. The median age was 75 years (interquartile range [IQR] = 69–81), 365 (58%) patients were female, 111 (18%) were nonwhite, 351 (56%) were admitted to the hospital, and 108 (17%) were delirious in the ED. Median LOS was 2 days (IQR = 0–5.5) for delirious ED patients and 1 day (IQR = 0–3) for nondelirious ED patients (p &lt; 0.001). The hazard ratio (HR) of delirium for time to discharge was 0.71 (95% confidence interval [CI] = 0.57 to 0.89) after adjusting for confounders, and indicated that ED patients with delirium were more likely to have prolonged hospital LOS compared with those without delirium. For the sensitivity analysis, which included only hospitalized patients, the adjusted HR was 0.76 (95% CI = 0.58 to 0.99). Conclusions:  Delirium in older ED patients has negative consequences and is an independent predictor of prolonged hospitalizations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21521405</pmid><doi>10.1111/j.1553-2712.2011.01065.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Academic Medical Centers
Aged
Aged, 80 and over
Delirium
Delirium - diagnosis
Delirium - epidemiology
Delirium - therapy
Emergency medical care
Emergency Service, Hospital
Female
Geriatric Assessment
Hospitalization
Hospitalization - statistics & numerical data
Humans
Length of Stay - statistics & numerical data
Male
Patients
Prognosis
Proportional Hazards Models
Prospective Studies
Studies
title Delirium in Older Emergency Department Patients Is an Independent Predictor of Hospital Length of Stay
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