Crystal Structure of a Human Prion Protein Fragment Reveals a Motif for Oligomer Formation

The structural transition of the prion protein from α-helical- to β-sheet-rich underlies its conversion into infectious and disease-associated isoforms. Here we describe the crystal structure of a fragment from human prion protein consisting of the disulfide-bond-linked portions of helices 2 and 3....

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Veröffentlicht in:	J. Am. Chem. Soc 2013-07, Vol.135 (28), p.10202-10205
Hauptverfasser:	Apostol, Marcin I, Perry, Kay, Surewicz, Witold K
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Humans Models, Molecular Prions - chemistry Protein Conformation
Online-Zugang:	Volltext
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