Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides, and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis
Increased uric acid (UA) is strongly linked to cardiovascular disease. However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensit...
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| Veröffentlicht in: | The American journal of cardiology 2012-12, Vol.110 (12), p.1787-1792 |
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| creator | Keenan, Tanya, MPH Blaha, Michael J., MD, MPH Nasir, Khurram, MD, MPH Silverman, Michael G., MD Tota-Maharaj, Rajesh, MD Carvalho, Jose A.M., MD Conceição, Raquel D., MD Blumenthal, Roger S., MD Santos, Raul D., MD, PhD |
| description | Increased uric acid (UA) is strongly linked to cardiovascular disease. However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensitivity C-reactive protein (hs-CRP), increased ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), sonographically detected hepatic steatosis, and their clustering in the presence and absence of obesity and metabolic syndrome. We evaluated 3,518 employed subjects without clinical cardiovascular disease from November 2008 through July 2010. Prevalence of hs-CRP ≥3 mg/L was 19%, that of TG/HDL ≥3 was 44%, and that of hepatic steatosis was 43%. In multivariable logistic regression after adjusting for traditional cardiovascular risk factors and confounders, highest versus lowest UA quartile was associated with hs-CRP ≥3 mg/L (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.01 to 2.28, p = 0.04), TG/HDL ≥3 (OR 3.29, 95% CI 2.36 to 4.60, p |
| doi_str_mv | 10.1016/j.amjcard.2012.08.012 |
| format | Article |
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However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensitivity C-reactive protein (hs-CRP), increased ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), sonographically detected hepatic steatosis, and their clustering in the presence and absence of obesity and metabolic syndrome. We evaluated 3,518 employed subjects without clinical cardiovascular disease from November 2008 through July 2010. Prevalence of hs-CRP ≥3 mg/L was 19%, that of TG/HDL ≥3 was 44%, and that of hepatic steatosis was 43%. In multivariable logistic regression after adjusting for traditional cardiovascular risk factors and confounders, highest versus lowest UA quartile was associated with hs-CRP ≥3 mg/L (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.01 to 2.28, p = 0.04), TG/HDL ≥3 (OR 3.29, 95% CI 2.36 to 4.60, p <0.001), and hepatic steatosis (OR 3.10, 95% CI 2.22 to 4.32, p <0.001) independently of obesity and metabolic syndrome. Association of UA with hs-CRP ≥3 mg/L became nonsignificant in analyses stratified by obesity. Ascending UA quartiles compared to the lowest UA quartile demonstrated a graded increase in the odds of having 2 or 3 of these risk conditions and a successive decrease in the odds of having none. In conclusion, high UA levels were associated with increased TG/HDL and hepatic steatosis independently of metabolic syndrome and obesity and with increased hs-CRP independently of metabolic syndrome.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2012.08.012</identifier><identifier>PMID: 22975466</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular ; Cholesterol ; Cholesterol, HDL - blood ; Diet ; Fatty Liver - blood ; Fatty Liver - complications ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Insulin resistance ; Linear Models ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - complications ; Other diseases. Semiology ; Prevalence ; Proteins ; Risk Factors ; Surveys and Questionnaires ; Triglycerides - blood ; Uric Acid - blood ; Young Adult</subject><ispartof>The American journal of cardiology, 2012-12, Vol.110 (12), p.1787-1792</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c646t-5967f565310df33fdcaf3f71a8cfc83ad64b70fbe5949b904e94c7feea8742a63</citedby><cites>FETCH-LOGICAL-c646t-5967f565310df33fdcaf3f71a8cfc83ad64b70fbe5949b904e94c7feea8742a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000291491201939X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26727443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22975466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keenan, Tanya, MPH</creatorcontrib><creatorcontrib>Blaha, Michael J., MD, MPH</creatorcontrib><creatorcontrib>Nasir, Khurram, MD, MPH</creatorcontrib><creatorcontrib>Silverman, Michael G., MD</creatorcontrib><creatorcontrib>Tota-Maharaj, Rajesh, MD</creatorcontrib><creatorcontrib>Carvalho, Jose A.M., MD</creatorcontrib><creatorcontrib>Conceição, Raquel D., MD</creatorcontrib><creatorcontrib>Blumenthal, Roger S., MD</creatorcontrib><creatorcontrib>Santos, Raul D., MD, PhD</creatorcontrib><title>Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides, and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Increased uric acid (UA) is strongly linked to cardiovascular disease. However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensitivity C-reactive protein (hs-CRP), increased ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), sonographically detected hepatic steatosis, and their clustering in the presence and absence of obesity and metabolic syndrome. We evaluated 3,518 employed subjects without clinical cardiovascular disease from November 2008 through July 2010. Prevalence of hs-CRP ≥3 mg/L was 19%, that of TG/HDL ≥3 was 44%, and that of hepatic steatosis was 43%. In multivariable logistic regression after adjusting for traditional cardiovascular risk factors and confounders, highest versus lowest UA quartile was associated with hs-CRP ≥3 mg/L (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.01 to 2.28, p = 0.04), TG/HDL ≥3 (OR 3.29, 95% CI 2.36 to 4.60, p <0.001), and hepatic steatosis (OR 3.10, 95% CI 2.22 to 4.32, p <0.001) independently of obesity and metabolic syndrome. Association of UA with hs-CRP ≥3 mg/L became nonsignificant in analyses stratified by obesity. Ascending UA quartiles compared to the lowest UA quartile demonstrated a graded increase in the odds of having 2 or 3 of these risk conditions and a successive decrease in the odds of having none. In conclusion, high UA levels were associated with increased TG/HDL and hepatic steatosis independently of metabolic syndrome and obesity and with increased hs-CRP independently of metabolic syndrome.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Diet</subject><subject>Fatty Liver - blood</subject><subject>Fatty Liver - complications</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Linear Models</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Other diseases. Semiology</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Triglycerides - blood</subject><subject>Uric Acid - blood</subject><subject>Young Adult</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkttuEzEQhlcIREvhEUCWEBIX3WCvvd71TVEVDkGKBGpaiTvL8Y6TCZt1sDeR8jI8K94mtNAbrkYjf_8cPH-WvWR0xCiT71Yjs15ZE5pRQVkxovUohUfZKasrlTPF-OPslFJa5IoJdZI9i3GVUsZK-TQ7KQpVlULK0-zXFbSmR98R78hNQEsuLTak92QGYbsmU9hBG4fHCS6W-Qy6iD3usN-TcX4FxqYEyLfge8DunFwHXLR7CwEbiOfEdM1B9-FWtydT3PjNASbjpW8h9hB8ewumnhPYpGEsmfVgeh8xPs-eONNGeHGMZ9nNp4_X40k-_fr5y_hymlspZJ-XSlaulCVntHGcu8Yax13FTG2drblppJhX1M2hVELNFRWghK0cgKkrURjJz7KLQ93Ndr6GxkLXB9PqTcC1CXvtDep_Xzpc6oXfaV5JWYsyFXh7LBD8z21aS68xWmhb04HfRs2KgjHOakkT-voBuvLb0KX1EkVrwaWseKLKA2WDjzGAuxuGUT04QK_00QF6cICmtU4h6V79vcmd6s_JE_DmCJhoTeuC6SzGe05WRSXEMMD7A5fuDzuEoKNF6Cw0GMD2uvH431EuHlSwLXaYmv6APcT7rXVMGj0b7Dq4Nf0CU1x9578B7jPpTw</recordid><startdate>20121215</startdate><enddate>20121215</enddate><creator>Keenan, Tanya, MPH</creator><creator>Blaha, Michael J., MD, MPH</creator><creator>Nasir, Khurram, MD, MPH</creator><creator>Silverman, Michael G., MD</creator><creator>Tota-Maharaj, Rajesh, MD</creator><creator>Carvalho, Jose A.M., MD</creator><creator>Conceição, Raquel D., MD</creator><creator>Blumenthal, Roger S., MD</creator><creator>Santos, Raul D., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121215</creationdate><title>Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides, and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis</title><author>Keenan, Tanya, MPH ; Blaha, Michael J., MD, MPH ; Nasir, Khurram, MD, MPH ; Silverman, Michael G., MD ; Tota-Maharaj, Rajesh, MD ; Carvalho, Jose A.M., MD ; Conceição, Raquel D., MD ; Blumenthal, Roger S., MD ; Santos, Raul D., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c646t-5967f565310df33fdcaf3f71a8cfc83ad64b70fbe5949b904e94c7feea8742a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Diet</topic><topic>Fatty Liver - blood</topic><topic>Fatty Liver - complications</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Linear Models</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Other diseases. Semiology</topic><topic>Prevalence</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Triglycerides - blood</topic><topic>Uric Acid - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keenan, Tanya, MPH</creatorcontrib><creatorcontrib>Blaha, Michael J., MD, MPH</creatorcontrib><creatorcontrib>Nasir, Khurram, MD, MPH</creatorcontrib><creatorcontrib>Silverman, Michael G., MD</creatorcontrib><creatorcontrib>Tota-Maharaj, Rajesh, MD</creatorcontrib><creatorcontrib>Carvalho, Jose A.M., MD</creatorcontrib><creatorcontrib>Conceição, Raquel D., MD</creatorcontrib><creatorcontrib>Blumenthal, Roger S., MD</creatorcontrib><creatorcontrib>Santos, Raul D., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keenan, Tanya, MPH</au><au>Blaha, Michael J., MD, MPH</au><au>Nasir, Khurram, MD, MPH</au><au>Silverman, Michael G., MD</au><au>Tota-Maharaj, Rajesh, MD</au><au>Carvalho, Jose A.M., MD</au><au>Conceição, Raquel D., MD</au><au>Blumenthal, Roger S., MD</au><au>Santos, Raul D., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides, and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2012-12-15</date><risdate>2012</risdate><volume>110</volume><issue>12</issue><spage>1787</spage><epage>1792</epage><pages>1787-1792</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Increased uric acid (UA) is strongly linked to cardiovascular disease. However, the independent role of UA is still debated because it is associated with several cardiovascular risk factors including obesity and metabolic syndrome. This study assessed the association of UA with increased high-sensitivity C-reactive protein (hs-CRP), increased ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL), sonographically detected hepatic steatosis, and their clustering in the presence and absence of obesity and metabolic syndrome. We evaluated 3,518 employed subjects without clinical cardiovascular disease from November 2008 through July 2010. Prevalence of hs-CRP ≥3 mg/L was 19%, that of TG/HDL ≥3 was 44%, and that of hepatic steatosis was 43%. In multivariable logistic regression after adjusting for traditional cardiovascular risk factors and confounders, highest versus lowest UA quartile was associated with hs-CRP ≥3 mg/L (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.01 to 2.28, p = 0.04), TG/HDL ≥3 (OR 3.29, 95% CI 2.36 to 4.60, p <0.001), and hepatic steatosis (OR 3.10, 95% CI 2.22 to 4.32, p <0.001) independently of obesity and metabolic syndrome. Association of UA with hs-CRP ≥3 mg/L became nonsignificant in analyses stratified by obesity. Ascending UA quartiles compared to the lowest UA quartile demonstrated a graded increase in the odds of having 2 or 3 of these risk conditions and a successive decrease in the odds of having none. In conclusion, high UA levels were associated with increased TG/HDL and hepatic steatosis independently of metabolic syndrome and obesity and with increased hs-CRP independently of metabolic syndrome.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22975466</pmid><doi>10.1016/j.amjcard.2012.08.012</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of cardiology, 2012-12, Vol.110 (12), p.1787-1792 |
| issn | 0002-9149 1879-1913 |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular Cholesterol Cholesterol, HDL - blood Diet Fatty Liver - blood Fatty Liver - complications Female Gastroenterology. Liver. Pancreas. Abdomen Humans Insulin resistance Linear Models Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Metabolic Syndrome - blood Metabolic Syndrome - complications Middle Aged Obesity Obesity - blood Obesity - complications Other diseases. Semiology Prevalence Proteins Risk Factors Surveys and Questionnaires Triglycerides - blood Uric Acid - blood Young Adult |
| title | Relation of Uric Acid to Serum Levels of High-Sensitivity C-Reactive Protein, Triglycerides, and High-Density Lipoprotein Cholesterol and to Hepatic Steatosis |
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