Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans
GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose me...
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| Veröffentlicht in: | Cardiovascular Diabetology 2013-08, Vol.12 (1), p.117-117, Article 117 |
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| creator | Piotrowski, Katja Becker, Melanie Zugwurst, Julia Biller-Friedmann, Ingeborg Spoettl, Gerald Greif, Martin Leber, Alexander W Becker, Alexander Laubender, Rüdiger P Lebherz, Corinna Goeke, Burkhard Marx, Nikolaus Parhofer, Klaus G Lehrke, Michael |
| description | GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for GLP-1 in experimental models. Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study.
GLP-1 serum levels were assessed in a cohort of 303 patients receiving coronary CT-angiography due to typical or atypical chest pain.
GLP-1 was found to be positively associated with total coronary plaque burden in a fully adjusted model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, triglycerides, LDL-C (low density lipoprotein cholesterol), hsCRP (high-sensitive C-reactive protein), and eGFR (estimated glomerular filtration rate) (OR: 2.53 (95% CI: 1.12 - 6.08; p = 0.03).
Circulating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations. |
| doi_str_mv | 10.1186/1475-2840-12-117 |
| format | Article |
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GLP-1 serum levels were assessed in a cohort of 303 patients receiving coronary CT-angiography due to typical or atypical chest pain.
GLP-1 was found to be positively associated with total coronary plaque burden in a fully adjusted model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, triglycerides, LDL-C (low density lipoprotein cholesterol), hsCRP (high-sensitive C-reactive protein), and eGFR (estimated glomerular filtration rate) (OR: 2.53 (95% CI: 1.12 - 6.08; p = 0.03).
Circulating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations.</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/1475-2840-12-117</identifier><identifier>PMID: 23953602</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Analysis ; Atherosclerosis ; Biomarkers - blood ; C-reactive protein ; Cardiovascular disease ; Coronary Angiography - methods ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Vessels - diagnostic imaging ; Diabetes ; Female ; Glucagon-Like Peptide 1 - blood ; Health aspects ; Heart attacks ; Humans ; Hypertension ; Insulin ; Insulin resistance ; Low density lipoproteins ; Male ; Medical research ; Medicine, Experimental ; Metabolic disorders ; Metabolites ; Middle Aged ; Multidetector Computed Tomography ; Original Investigation ; Peptide hormones ; Physiological aspects ; Plaque, Atherosclerotic ; Risk factors ; Severity of Illness Index ; Studies ; Triglycerides</subject><ispartof>Cardiovascular Diabetology, 2013-08, Vol.12 (1), p.117-117, Article 117</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Piotrowski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Piotrowski et al.; licensee BioMed Central Ltd. 2013 Piotrowski et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b551t-ffc06bdd1831bace8a5b6809ca019639d109c6945b34c50a3088720e601216dc3</citedby><cites>FETCH-LOGICAL-b551t-ffc06bdd1831bace8a5b6809ca019639d109c6945b34c50a3088720e601216dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765863/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765863/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23953602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piotrowski, Katja</creatorcontrib><creatorcontrib>Becker, Melanie</creatorcontrib><creatorcontrib>Zugwurst, Julia</creatorcontrib><creatorcontrib>Biller-Friedmann, Ingeborg</creatorcontrib><creatorcontrib>Spoettl, Gerald</creatorcontrib><creatorcontrib>Greif, Martin</creatorcontrib><creatorcontrib>Leber, Alexander W</creatorcontrib><creatorcontrib>Becker, Alexander</creatorcontrib><creatorcontrib>Laubender, Rüdiger P</creatorcontrib><creatorcontrib>Lebherz, Corinna</creatorcontrib><creatorcontrib>Goeke, Burkhard</creatorcontrib><creatorcontrib>Marx, Nikolaus</creatorcontrib><creatorcontrib>Parhofer, Klaus G</creatorcontrib><creatorcontrib>Lehrke, Michael</creatorcontrib><title>Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans</title><title>Cardiovascular Diabetology</title><addtitle>Cardiovasc Diabetol</addtitle><description>GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for GLP-1 in experimental models. Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study.
GLP-1 serum levels were assessed in a cohort of 303 patients receiving coronary CT-angiography due to typical or atypical chest pain.
GLP-1 was found to be positively associated with total coronary plaque burden in a fully adjusted model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, triglycerides, LDL-C (low density lipoprotein cholesterol), hsCRP (high-sensitive C-reactive protein), and eGFR (estimated glomerular filtration rate) (OR: 2.53 (95% CI: 1.12 - 6.08; p = 0.03).
Circulating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations.</description><subject>Aged</subject><subject>Analysis</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>Cardiovascular disease</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Diabetes</subject><subject>Female</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Health aspects</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolic disorders</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Multidetector Computed Tomography</subject><subject>Original Investigation</subject><subject>Peptide hormones</subject><subject>Physiological aspects</subject><subject>Plaque, Atherosclerotic</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Studies</subject><subject>Triglycerides</subject><issn>1475-2840</issn><issn>1475-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UkFrFTEQDqLYWr17koAXL1szm002uQjlYavwQA968RKy2ex7KbtJTXYr_vvOY-ujFSWQTCbffJn5Zgh5DewcQMn30LSiqlXDKqgrgPYJOT26nj6wT8iLUq4Zg1ZJeE5Oaq4Fl6w-JT82IbtltHOIO-pSdD7OGW8pFpoGerX9WgG12VNbSnLBzr6nv8K8R2xO0ebf1M57n1Nx42EPhYZI98tkY3lJng12LP7V_XlGvl9-_Lb5VG2_XH3eXGyrTgiYq2FwTHZ9D4pDZ51XVnRSMe0sAy257gFtqRvR8cYJZjlTqq2ZlwxqkL3jZ-TDynuzdJPv1wpGc5PDhPmZZIN5_BLD3uzSreGtFEpyJNisBF1I_yF4_OLSZA7amoO2BmqD0iPLu_s0cvq5-DKbKRTnx9FGn5aCAUJDo3l7gL79C3qdlhxRJETVutWARSLqfEXt7OhNiEPCzx2u3k8BW-WHgP4LwRspQCrAALYGOOxEyX44lgCYJc7Lv5J-81C7Y8CfAeF3mDS7nA</recordid><startdate>20130816</startdate><enddate>20130816</enddate><creator>Piotrowski, Katja</creator><creator>Becker, Melanie</creator><creator>Zugwurst, Julia</creator><creator>Biller-Friedmann, Ingeborg</creator><creator>Spoettl, Gerald</creator><creator>Greif, Martin</creator><creator>Leber, Alexander W</creator><creator>Becker, Alexander</creator><creator>Laubender, Rüdiger P</creator><creator>Lebherz, Corinna</creator><creator>Goeke, Burkhard</creator><creator>Marx, Nikolaus</creator><creator>Parhofer, Klaus G</creator><creator>Lehrke, Michael</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130816</creationdate><title>Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans</title><author>Piotrowski, Katja ; Becker, Melanie ; Zugwurst, Julia ; Biller-Friedmann, Ingeborg ; Spoettl, Gerald ; Greif, Martin ; Leber, Alexander W ; Becker, Alexander ; Laubender, Rüdiger P ; Lebherz, Corinna ; Goeke, Burkhard ; Marx, Nikolaus ; Parhofer, Klaus G ; Lehrke, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b551t-ffc06bdd1831bace8a5b6809ca019639d109c6945b34c50a3088720e601216dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>Cardiovascular disease</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Diabetes</topic><topic>Female</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Health aspects</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metabolic disorders</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Multidetector Computed Tomography</topic><topic>Original Investigation</topic><topic>Peptide hormones</topic><topic>Physiological aspects</topic><topic>Plaque, Atherosclerotic</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Studies</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piotrowski, Katja</creatorcontrib><creatorcontrib>Becker, Melanie</creatorcontrib><creatorcontrib>Zugwurst, Julia</creatorcontrib><creatorcontrib>Biller-Friedmann, Ingeborg</creatorcontrib><creatorcontrib>Spoettl, Gerald</creatorcontrib><creatorcontrib>Greif, Martin</creatorcontrib><creatorcontrib>Leber, Alexander W</creatorcontrib><creatorcontrib>Becker, Alexander</creatorcontrib><creatorcontrib>Laubender, Rüdiger P</creatorcontrib><creatorcontrib>Lebherz, Corinna</creatorcontrib><creatorcontrib>Goeke, Burkhard</creatorcontrib><creatorcontrib>Marx, Nikolaus</creatorcontrib><creatorcontrib>Parhofer, Klaus G</creatorcontrib><creatorcontrib>Lehrke, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular Diabetology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piotrowski, Katja</au><au>Becker, Melanie</au><au>Zugwurst, Julia</au><au>Biller-Friedmann, Ingeborg</au><au>Spoettl, Gerald</au><au>Greif, Martin</au><au>Leber, Alexander W</au><au>Becker, Alexander</au><au>Laubender, Rüdiger P</au><au>Lebherz, Corinna</au><au>Goeke, Burkhard</au><au>Marx, Nikolaus</au><au>Parhofer, Klaus G</au><au>Lehrke, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans</atitle><jtitle>Cardiovascular Diabetology</jtitle><addtitle>Cardiovasc Diabetol</addtitle><date>2013-08-16</date><risdate>2013</risdate><volume>12</volume><issue>1</issue><spage>117</spage><epage>117</epage><pages>117-117</pages><artnum>117</artnum><issn>1475-2840</issn><eissn>1475-2840</eissn><abstract>GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for GLP-1 in experimental models. Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study.
GLP-1 serum levels were assessed in a cohort of 303 patients receiving coronary CT-angiography due to typical or atypical chest pain.
GLP-1 was found to be positively associated with total coronary plaque burden in a fully adjusted model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, triglycerides, LDL-C (low density lipoprotein cholesterol), hsCRP (high-sensitive C-reactive protein), and eGFR (estimated glomerular filtration rate) (OR: 2.53 (95% CI: 1.12 - 6.08; p = 0.03).
Circulating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23953602</pmid><doi>10.1186/1475-2840-12-117</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Aged Analysis Atherosclerosis Biomarkers - blood C-reactive protein Cardiovascular disease Coronary Angiography - methods Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Vessels - diagnostic imaging Diabetes Female Glucagon-Like Peptide 1 - blood Health aspects Heart attacks Humans Hypertension Insulin Insulin resistance Low density lipoproteins Male Medical research Medicine, Experimental Metabolic disorders Metabolites Middle Aged Multidetector Computed Tomography Original Investigation Peptide hormones Physiological aspects Plaque, Atherosclerotic Risk factors Severity of Illness Index Studies Triglycerides |
| title | Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans |
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