Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate - induced mitochondrial damage and increased oxido-nitrosative stress in the kidney

Nephrotoxicity is a dose limiting side effect of tenofovir, a reverse transcriptase inhibitor that is used for the treatment of HIV infection. The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir is specifically toxic to the proximal convoluted tubules and proximal tubular mitochondria...

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Veröffentlicht in:	Journal of biomedical science 2013-08, Vol.20 (1), p.61-61
Hauptverfasser:	Abraham, Premila, Ramamoorthy, Hemalatha, Isaac, Bina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Animals Antioxidants Antioxidants - metabolism Dehydrogenases DNA polymerases Drug dosages Enzymes Glutathione - metabolism Glutathione Peroxidase - metabolism Health aspects HIV infection Human immunodeficiency virus Kidney - drug effects Kidney - injuries Kidney - pathology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Kidney Tubules, Proximal - pathology Kidneys Lipids Microscopy Mitochondria Mitochondria - drug effects Mitochondria - enzymology Mitochondria - metabolism Mitochondrial Diseases - chemically induced Mitochondrial Diseases - metabolism Mitochondrial Diseases - pathology Nitric oxide Organophosphonates - administration & dosage Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Proteins Rats Rats, Wistar Rodents Superoxide Superoxide Dismutase - metabolism Tenofovir Toxicity
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