Ubiquitin Interacts with the Tollip C2 and CUE Domains and Inhibits Binding of Tollip to Phosphoinositides

A large number of cellular signaling processes are directed through internalization, via endocytosis, of polyubiquitinated cargo proteins. Tollip is an adaptor protein that facilitates endosomal cargo sorting for lysosomal degradation. Tollip preferentially binds phosphatidylinositol 3-phosphate (Pt...

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Veröffentlicht in:	The Journal of biological chemistry 2013-09, Vol.288 (36), p.25780-25791
Hauptverfasser:	Mitra, Sharmistha, Traughber, C. Alicia, Brannon, Mary K., Gomez, Stephanie, Capelluto, Daniel G.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Endosomes Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Membrane Trafficking Models, Biological Molecular Biophysics Nuclear Magnetic Resonance Nuclear Magnetic Resonance, Biomolecular Phosphatidylinositols - chemistry Phosphatidylinositols - genetics Phosphatidylinositols - metabolism Phosphoinositides Protein Binding Protein Structure, Tertiary Protein Transport Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Ubiquitin Ubiquitin - chemistry Ubiquitin - genetics Ubiquitin - metabolism
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