HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis‐related morbidity

The risk of hemochromatosis‐related morbidity is unknown among HFE compound heterozygotes (C282Y/H63D). We used a prospective population‐based cohort study to estimate the prevalence of elevated iron indices and hemochromatosis‐related morbidity for compound heterozygotes. In all, 31,192 subjects of...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2009-07, Vol.50 (1), p.94-101
Hauptverfasser:	Gurrin, Lyle C., Bertalli, Nadine A., Dalton, Gregory W., Osborne, Nicholas J., Constantine, Clare C., McLaren, Christine E., English, Dallas R., Gertig, Dorota M., Delatycki, Martin B., Nicoll, Amanda J., Southey, Melissa C., Hopper, John L., Giles, Graham G., Anderson, Gregory J., Olynyk, John K., Powell, Lawrie W., Allen, Katrina J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Hemochromatosis - complications Hemochromatosis - genetics Hemochromatosis Protein Heterozygote Histocompatibility Antigens Class I - genetics Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Membrane Proteins - genetics Metabolic diseases Metals (hemochromatosis...) Middle Aged Other metabolic disorders Prospective Studies Risk Factors
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