Sustained Release of Matrix Metalloproteinase‑3 to Trabecular Meshwork Cells Using Biodegradable PLGA Microparticles

Accumulation of extracellular matrix (ECM) materials in the trabecular meshwork (TM) is believed to be a contributing factor to intraocular pressure (IOP) elevation, a risk factor/cause of primary open angle glaucoma, a major blinding disease. Matrix metalloproteinase-3 (MMP-3) is one of the protein...

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Veröffentlicht in:	Molecular pharmaceutics 2013-08, Vol.10 (8), p.3023-3032
Hauptverfasser:	Turturro, Sanja, Sunoqrot, Suhair, Ying, Hongyu, Hong, Seungpyo, Yue, Beatrice Y. J. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Glaucoma - metabolism Humans In Vitro Techniques Lactic Acid - chemistry Matrix Metalloproteinase 3 - chemistry Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase 3 - pharmacokinetics Microscopy, Electron, Scanning Particle Size Polyglycolic Acid - chemistry Trabecular Meshwork - cytology Trabecular Meshwork - metabolism
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