Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy

Abstract The application of RNA interference (RNAi) for inﬂammatory bowel disease (IBD) therapy has been limited by the lack of non-cytotoxic, efficient and targetable small interfering RNA (siRNA) carriers. TNF-α is the major pro-inflammatory cytokine mainly secreted by macrophages during IBD. Here...

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Veröffentlicht in:	Biomaterials 2013-10, Vol.34 (30), p.7471-7482
Hauptverfasser:	Xiao, Bo, Laroui, Hamed, Ayyadurai, Saravanan, Viennois, Emilie, Charania, Moiz A, Zhang, Yuchen, Merlin, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Bioreducible polymer Caco-2 Cells Cell Death - drug effects Dentistry Electrophoresis, Agar Gel Endocytosis - drug effects Humans IBD therapy Inflammatory Bowel Diseases - therapy Macrophage-targeted delivery Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Male Mannose - metabolism Mannosylation Mice Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Polyphosphates - chemistry Polyphosphates - pharmacology RNA interference RNA Interference - drug effects RNA, Small Interfering - metabolism Titrimetry Tumor Necrosis Factor-alpha - metabolism
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