The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol

Besides its quintessential role in reproduction, 17β-estradiol (E2) is a potent anorexigenic hormone. E2 and the selective Gq-coupled membrane estrogen receptor (Gq-mER) ligand STX rapidly increase membrane excitability in proopiomelanocortin (POMC) neurons by desensitizing the coupling of GABAB rec...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2013-09, Vol.305 (5), p.E632-E640
Hauptverfasser:	Smith, A W, Bosch, M A, Wagner, E J, Rønnekleiv, O K, Kelly, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - metabolism Acrylamides - pharmacology Animals Baclofen - pharmacology Estradiol - metabolism Estradiol - pharmacology Estrogen Receptor alpha - metabolism Female GABA-B Receptor Agonists - pharmacology Guinea Pigs Hypothalamus - metabolism Male Mice Mice, Transgenic Neurons - metabolism Neuropeptide Y - metabolism Patch-Clamp Techniques Receptors, GABA-B - metabolism Signal Transduction
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