Influence of CYP2C82 on the Pharmacokinetics of Pioglitazone in Healthy African-American Volunteers

Study Objectives To determine the influence of the Cytochrome P450 (CYP) 2C8*2 polymorphism on pioglitazone pharmacokinetics in healthy African‐American volunteers. Design Prospective, open‐label, single‐dose pharmacokinetic study. Setting University of Colorado Hospital Clinical and Translational R...

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Veröffentlicht in:	Pharmacotherapy 2013-09, Vol.33 (9), p.1000-1007
Hauptverfasser:	Aquilante, Christina L., Wempe, Michael F., Spencer, Samantha H., Kosmiski, Lisa A., Predhomme, Julie A., Sidhom, Maha S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans - genetics African-American Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences CYP2C8 Cytochrome P-450 CYP2C8 Female Gene Frequency Genotype Healthy Volunteers Humans Hypoglycemic Agents - pharmacokinetics Male Medical sciences Middle Aged pharmacogenetics pharmacokinetics Pharmacology. Drug treatments pioglitazone polymorphism Polymorphism, Genetic - genetics Thiazolidinediones - pharmacokinetics
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