Activation of Notch-Mediated Protective Signaling in the Myocardium

The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and regeneration. These processes are regulated via Notch-mediated activity that involves hepatocyte growth factor (HGF)/c-Met receptor and phosphatidyl...

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Veröffentlicht in:	Circulation research 2008-05, Vol.102 (9), p.1025-1035
Hauptverfasser:	Gude, Natalie A, Emmanuel, Gregory, Wu, Weitao, Cottage, Christopher T, Fischer, Kimberlee, Quijada, Pearl, Muraski, John A, Alvarez, Roberto, Rubio, Marta, Schaefer, Eric, Sussman, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Biological and medical sciences Cell Proliferation Cells, Cultured Disease Models, Animal Enzyme Activation Feedback, Physiological Female Fundamental and applied biological sciences. Psychology Hemodynamics Hepatocyte Growth Factor - metabolism Homeodomain Proteins - metabolism Insulin - metabolism Male Mice Mice, Inbred C57BL Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor Protein-Tyrosine Kinases - metabolism Receptor, Notch1 - metabolism Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction Time Factors Transcription Factor HES-1 Transduction, Genetic Vertebrates: cardiovascular system
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