AKT in stromal fibroblasts controls invasion of epithelial cells

The tumour microenvironment has an important role in cancer progression and recent reports have proposed that stromal AKT is activated and regulates tumourigenesis and invasion. We have shown, by immuno-fluorescent analysis of oro-pharyngeal cancer biopsies, an increase in AKT activity in tumour ass...

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Veröffentlicht in:	Oncotarget 2013-07, Vol.4 (7), p.1103-1116
Hauptverfasser:	Cichon, Ann-Christin, Pickard, Adam, McDade, Simon S, Sharpe, Daniel J, Moran, Michael, James, Jacqueline A, McCance, Dennis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis - metabolism Carcinogenesis - pathology Cells, Cultured Disease Progression Epithelial Cells - enzymology Epithelial Cells - pathology Fibroblasts - enzymology Fibroblasts - pathology Humans Keratinocytes - enzymology Keratinocytes - pathology Oropharyngeal Neoplasms - enzymology Oropharyngeal Neoplasms - pathology Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Research Papers Stromal Cells - enzymology Stromal Cells - pathology Tumor Microenvironment
Online-Zugang:	Volltext
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