Coenzyme depletion by members of the aerolysin family of pore-forming toxins leads to diminished ATP levels and cell death

Recent studies demonstrated that a variety of bacterial pore-forming toxins induce cell death through a process of programmed necrosis characterized by the rapid depletion of cellular ATP. However, events leading to the necrosis and depletion of ATP are not thoroughly understood. We demonstrate that...

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Veröffentlicht in:	Molecular bioSystems 2012-08, Vol.8 (8), p.2097-2105
Hauptverfasser:	Fennessey, Christine M, Ivie, Susan E, McClain, Mark S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aeromonas Aeromonas hydrophila - chemistry Bacterial Toxins - pharmacology Carnitine - metabolism Cell Death - drug effects Cell Line Clostridium Coenzyme A - metabolism Humans NAD - metabolism Pore Forming Cytotoxic Proteins - pharmacology
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