Generalization of adiposity genetic loci to US Hispanic women
BACKGROUND: Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown. OBJECTIVE: To interrogate an a priori list of 47 (32 overall body mass and 15 central adip...
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| creator | Graff, M Fernández-Rhodes, L Liu, S Carlson, C Wassertheil-Smoller, S Neuhouser, M Reiner, A Kooperberg, C Rampersaud, E Manson, J E Kuller, L H Howard, B V Ochs-Balcom, H M Johnson, K C Vitolins, M Z Sucheston, L Monda, K North, K E |
| description | BACKGROUND:
Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown.
OBJECTIVE:
To interrogate an
a priori
list of 47 (32 overall body mass and 15 central adiposity) index single-nucleotide polymorphisms (SNPs) previously studied in individuals of European descent among 3494 US Hispanic women in the Women’s Health Initiative SNP Health Association Resource (WHI SHARe).
DESIGN:
Cross-sectional analysis of measured body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were inverse normally transformed after adjusting for age, smoking, center and global ancestry. WC and WHR models were also adjusted for BMI. Genotyping was performed using the Affymetrix 6.0 array. In the absence of an
a priori
selected SNP, a proxy was selected (
r
2
⩾0.8 in CEU).
RESULTS:
Six BMI loci (
TMEM18, NUDT3/HMGA1, FAIM2, FTO, MC4R
and
KCTD15
) and two WC/WHR loci (
VEGFA
and
ITPR2-SSPN
) were nominally significant
(P<
0.05) at the index or proxy SNP in the corresponding BMI and WC/WHR models. To account for distinct linkage disequilibrium patterns in Hispanics and further assess generalization of genetic effects at each locus, we interrogated the evidence for association at the 47 surrounding loci within 1 Mb region of the index or proxy SNP. Three additional BMI loci (
FANCL, TFAP2B
and
ETV5
) and five WC/WHR loci (
DNM3-PIGC, GRB14, ADAMTS9, LY86
and
MSRA)
displayed Bonferroni-corrected significant associations with BMI and WC/WHR. Conditional analyses of each index SNP (or its proxy) and the most significant SNP within the 1 Mb region supported the possible presence of index-independent signals at each of these eight loci as well as at
KCTD15
.
CONCLUSION:
This study provides evidence for the generalization of nine BMI and seven central adiposity loci in Hispanic women. This study expands the current knowledge of common adiposity-related genetic loci to Hispanic women. |
| doi_str_mv | 10.1038/nutd.2013.26 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3759132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1428516195</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-42441bcb6774411785e1c9c80ed81f7f87a628b2d4dffcdc60a8e69ef954c9033</originalsourceid><addsrcrecordid>eNptkcFLwzAYxYMobszdPEvBiwc7kzRN04OCDN2EgQfdOaRpOjPapDatMv96UzbHFHPJR96Pl_fxADhHcIJgxG5M1-YTDFE0wfQIDDEkJCQwxscH8wCMnVtDfyjEjLJTMMBRmjCG0iG4nSmjGlHqL9FqawJbBCLXtXW63QQrr7VaBqWVOmhtsHwJ5trVwvi3T1spcwZOClE6Nd7dI7B8fHidzsPF8-xper8IZYxoGxJMCMpkRpPEDyhhsUIylQyqnKEiKVgiKGYZzkleFDKXFAqmaKqKNCYyhVE0Andb37rLKpVLZVqfmdeNrkSz4VZo_lsx-o2v7AePkjhFEfYGVzuDxr53yrW80k6qshRG2c5xRDDzUVEae_TyD7q2XWP8etwnZ5AkCPWG11tKNta5RhX7MAjyvhreV8P7ajimHr84XGAP_xThgXALOC-ZlWoOfv3P8BuiVZj-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1788047112</pqid></control><display><type>article</type><title>Generalization of adiposity genetic loci to US Hispanic women</title><source>Springer Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Graff, M ; Fernández-Rhodes, L ; Liu, S ; Carlson, C ; Wassertheil-Smoller, S ; Neuhouser, M ; Reiner, A ; Kooperberg, C ; Rampersaud, E ; Manson, J E ; Kuller, L H ; Howard, B V ; Ochs-Balcom, H M ; Johnson, K C ; Vitolins, M Z ; Sucheston, L ; Monda, K ; North, K E</creator><creatorcontrib>Graff, M ; Fernández-Rhodes, L ; Liu, S ; Carlson, C ; Wassertheil-Smoller, S ; Neuhouser, M ; Reiner, A ; Kooperberg, C ; Rampersaud, E ; Manson, J E ; Kuller, L H ; Howard, B V ; Ochs-Balcom, H M ; Johnson, K C ; Vitolins, M Z ; Sucheston, L ; Monda, K ; North, K E</creatorcontrib><description>BACKGROUND:
Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown.
OBJECTIVE:
To interrogate an
a priori
list of 47 (32 overall body mass and 15 central adiposity) index single-nucleotide polymorphisms (SNPs) previously studied in individuals of European descent among 3494 US Hispanic women in the Women’s Health Initiative SNP Health Association Resource (WHI SHARe).
DESIGN:
Cross-sectional analysis of measured body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were inverse normally transformed after adjusting for age, smoking, center and global ancestry. WC and WHR models were also adjusted for BMI. Genotyping was performed using the Affymetrix 6.0 array. In the absence of an
a priori
selected SNP, a proxy was selected (
r
2
⩾0.8 in CEU).
RESULTS:
Six BMI loci (
TMEM18, NUDT3/HMGA1, FAIM2, FTO, MC4R
and
KCTD15
) and two WC/WHR loci (
VEGFA
and
ITPR2-SSPN
) were nominally significant
(P<
0.05) at the index or proxy SNP in the corresponding BMI and WC/WHR models. To account for distinct linkage disequilibrium patterns in Hispanics and further assess generalization of genetic effects at each locus, we interrogated the evidence for association at the 47 surrounding loci within 1 Mb region of the index or proxy SNP. Three additional BMI loci (
FANCL, TFAP2B
and
ETV5
) and five WC/WHR loci (
DNM3-PIGC, GRB14, ADAMTS9, LY86
and
MSRA)
displayed Bonferroni-corrected significant associations with BMI and WC/WHR. Conditional analyses of each index SNP (or its proxy) and the most significant SNP within the 1 Mb region supported the possible presence of index-independent signals at each of these eight loci as well as at
KCTD15
.
CONCLUSION:
This study provides evidence for the generalization of nine BMI and seven central adiposity loci in Hispanic women. This study expands the current knowledge of common adiposity-related genetic loci to Hispanic women.</description><identifier>ISSN: 2044-4052</identifier><identifier>EISSN: 2044-4052</identifier><identifier>DOI: 10.1038/nutd.2013.26</identifier><identifier>PMID: 23978819</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/457/649 ; 692/699/2743/393 ; Clinical Nutrition ; Diabetes ; Epidemiology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original ; original-article</subject><ispartof>Nutrition & diabetes, 2013-08, Vol.3 (8), p.e85-e85</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group Aug 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-42441bcb6774411785e1c9c80ed81f7f87a628b2d4dffcdc60a8e69ef954c9033</citedby><cites>FETCH-LOGICAL-c516t-42441bcb6774411785e1c9c80ed81f7f87a628b2d4dffcdc60a8e69ef954c9033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759132/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759132/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23978819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graff, M</creatorcontrib><creatorcontrib>Fernández-Rhodes, L</creatorcontrib><creatorcontrib>Liu, S</creatorcontrib><creatorcontrib>Carlson, C</creatorcontrib><creatorcontrib>Wassertheil-Smoller, S</creatorcontrib><creatorcontrib>Neuhouser, M</creatorcontrib><creatorcontrib>Reiner, A</creatorcontrib><creatorcontrib>Kooperberg, C</creatorcontrib><creatorcontrib>Rampersaud, E</creatorcontrib><creatorcontrib>Manson, J E</creatorcontrib><creatorcontrib>Kuller, L H</creatorcontrib><creatorcontrib>Howard, B V</creatorcontrib><creatorcontrib>Ochs-Balcom, H M</creatorcontrib><creatorcontrib>Johnson, K C</creatorcontrib><creatorcontrib>Vitolins, M Z</creatorcontrib><creatorcontrib>Sucheston, L</creatorcontrib><creatorcontrib>Monda, K</creatorcontrib><creatorcontrib>North, K E</creatorcontrib><title>Generalization of adiposity genetic loci to US Hispanic women</title><title>Nutrition & diabetes</title><addtitle>Nutr & Diabetes</addtitle><addtitle>Nutr Diabetes</addtitle><description>BACKGROUND:
Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown.
OBJECTIVE:
To interrogate an
a priori
list of 47 (32 overall body mass and 15 central adiposity) index single-nucleotide polymorphisms (SNPs) previously studied in individuals of European descent among 3494 US Hispanic women in the Women’s Health Initiative SNP Health Association Resource (WHI SHARe).
DESIGN:
Cross-sectional analysis of measured body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were inverse normally transformed after adjusting for age, smoking, center and global ancestry. WC and WHR models were also adjusted for BMI. Genotyping was performed using the Affymetrix 6.0 array. In the absence of an
a priori
selected SNP, a proxy was selected (
r
2
⩾0.8 in CEU).
RESULTS:
Six BMI loci (
TMEM18, NUDT3/HMGA1, FAIM2, FTO, MC4R
and
KCTD15
) and two WC/WHR loci (
VEGFA
and
ITPR2-SSPN
) were nominally significant
(P<
0.05) at the index or proxy SNP in the corresponding BMI and WC/WHR models. To account for distinct linkage disequilibrium patterns in Hispanics and further assess generalization of genetic effects at each locus, we interrogated the evidence for association at the 47 surrounding loci within 1 Mb region of the index or proxy SNP. Three additional BMI loci (
FANCL, TFAP2B
and
ETV5
) and five WC/WHR loci (
DNM3-PIGC, GRB14, ADAMTS9, LY86
and
MSRA)
displayed Bonferroni-corrected significant associations with BMI and WC/WHR. Conditional analyses of each index SNP (or its proxy) and the most significant SNP within the 1 Mb region supported the possible presence of index-independent signals at each of these eight loci as well as at
KCTD15
.
CONCLUSION:
This study provides evidence for the generalization of nine BMI and seven central adiposity loci in Hispanic women. This study expands the current knowledge of common adiposity-related genetic loci to Hispanic women.</description><subject>631/208/457/649</subject><subject>692/699/2743/393</subject><subject>Clinical Nutrition</subject><subject>Diabetes</subject><subject>Epidemiology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original</subject><subject>original-article</subject><issn>2044-4052</issn><issn>2044-4052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNptkcFLwzAYxYMobszdPEvBiwc7kzRN04OCDN2EgQfdOaRpOjPapDatMv96UzbHFHPJR96Pl_fxADhHcIJgxG5M1-YTDFE0wfQIDDEkJCQwxscH8wCMnVtDfyjEjLJTMMBRmjCG0iG4nSmjGlHqL9FqawJbBCLXtXW63QQrr7VaBqWVOmhtsHwJ5trVwvi3T1spcwZOClE6Nd7dI7B8fHidzsPF8-xper8IZYxoGxJMCMpkRpPEDyhhsUIylQyqnKEiKVgiKGYZzkleFDKXFAqmaKqKNCYyhVE0Andb37rLKpVLZVqfmdeNrkSz4VZo_lsx-o2v7AePkjhFEfYGVzuDxr53yrW80k6qshRG2c5xRDDzUVEae_TyD7q2XWP8etwnZ5AkCPWG11tKNta5RhX7MAjyvhreV8P7ajimHr84XGAP_xThgXALOC-ZlWoOfv3P8BuiVZj-</recordid><startdate>20130826</startdate><enddate>20130826</enddate><creator>Graff, M</creator><creator>Fernández-Rhodes, L</creator><creator>Liu, S</creator><creator>Carlson, C</creator><creator>Wassertheil-Smoller, S</creator><creator>Neuhouser, M</creator><creator>Reiner, A</creator><creator>Kooperberg, C</creator><creator>Rampersaud, E</creator><creator>Manson, J E</creator><creator>Kuller, L H</creator><creator>Howard, B V</creator><creator>Ochs-Balcom, H M</creator><creator>Johnson, K C</creator><creator>Vitolins, M Z</creator><creator>Sucheston, L</creator><creator>Monda, K</creator><creator>North, K E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130826</creationdate><title>Generalization of adiposity genetic loci to US Hispanic women</title><author>Graff, M ; Fernández-Rhodes, L ; Liu, S ; Carlson, C ; Wassertheil-Smoller, S ; Neuhouser, M ; Reiner, A ; Kooperberg, C ; Rampersaud, E ; Manson, J E ; Kuller, L H ; Howard, B V ; Ochs-Balcom, H M ; Johnson, K C ; Vitolins, M Z ; Sucheston, L ; Monda, K ; North, K E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-42441bcb6774411785e1c9c80ed81f7f87a628b2d4dffcdc60a8e69ef954c9033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/208/457/649</topic><topic>692/699/2743/393</topic><topic>Clinical Nutrition</topic><topic>Diabetes</topic><topic>Epidemiology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original</topic><topic>original-article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graff, M</creatorcontrib><creatorcontrib>Fernández-Rhodes, L</creatorcontrib><creatorcontrib>Liu, S</creatorcontrib><creatorcontrib>Carlson, C</creatorcontrib><creatorcontrib>Wassertheil-Smoller, S</creatorcontrib><creatorcontrib>Neuhouser, M</creatorcontrib><creatorcontrib>Reiner, A</creatorcontrib><creatorcontrib>Kooperberg, C</creatorcontrib><creatorcontrib>Rampersaud, E</creatorcontrib><creatorcontrib>Manson, J E</creatorcontrib><creatorcontrib>Kuller, L H</creatorcontrib><creatorcontrib>Howard, B V</creatorcontrib><creatorcontrib>Ochs-Balcom, H M</creatorcontrib><creatorcontrib>Johnson, K C</creatorcontrib><creatorcontrib>Vitolins, M Z</creatorcontrib><creatorcontrib>Sucheston, L</creatorcontrib><creatorcontrib>Monda, K</creatorcontrib><creatorcontrib>North, K E</creatorcontrib><collection>Springer Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrition & diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graff, M</au><au>Fernández-Rhodes, L</au><au>Liu, S</au><au>Carlson, C</au><au>Wassertheil-Smoller, S</au><au>Neuhouser, M</au><au>Reiner, A</au><au>Kooperberg, C</au><au>Rampersaud, E</au><au>Manson, J E</au><au>Kuller, L H</au><au>Howard, B V</au><au>Ochs-Balcom, H M</au><au>Johnson, K C</au><au>Vitolins, M Z</au><au>Sucheston, L</au><au>Monda, K</au><au>North, K E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generalization of adiposity genetic loci to US Hispanic women</atitle><jtitle>Nutrition & diabetes</jtitle><stitle>Nutr & Diabetes</stitle><addtitle>Nutr Diabetes</addtitle><date>2013-08-26</date><risdate>2013</risdate><volume>3</volume><issue>8</issue><spage>e85</spage><epage>e85</epage><pages>e85-e85</pages><issn>2044-4052</issn><eissn>2044-4052</eissn><abstract>BACKGROUND:
Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown.
OBJECTIVE:
To interrogate an
a priori
list of 47 (32 overall body mass and 15 central adiposity) index single-nucleotide polymorphisms (SNPs) previously studied in individuals of European descent among 3494 US Hispanic women in the Women’s Health Initiative SNP Health Association Resource (WHI SHARe).
DESIGN:
Cross-sectional analysis of measured body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were inverse normally transformed after adjusting for age, smoking, center and global ancestry. WC and WHR models were also adjusted for BMI. Genotyping was performed using the Affymetrix 6.0 array. In the absence of an
a priori
selected SNP, a proxy was selected (
r
2
⩾0.8 in CEU).
RESULTS:
Six BMI loci (
TMEM18, NUDT3/HMGA1, FAIM2, FTO, MC4R
and
KCTD15
) and two WC/WHR loci (
VEGFA
and
ITPR2-SSPN
) were nominally significant
(P<
0.05) at the index or proxy SNP in the corresponding BMI and WC/WHR models. To account for distinct linkage disequilibrium patterns in Hispanics and further assess generalization of genetic effects at each locus, we interrogated the evidence for association at the 47 surrounding loci within 1 Mb region of the index or proxy SNP. Three additional BMI loci (
FANCL, TFAP2B
and
ETV5
) and five WC/WHR loci (
DNM3-PIGC, GRB14, ADAMTS9, LY86
and
MSRA)
displayed Bonferroni-corrected significant associations with BMI and WC/WHR. Conditional analyses of each index SNP (or its proxy) and the most significant SNP within the 1 Mb region supported the possible presence of index-independent signals at each of these eight loci as well as at
KCTD15
.
CONCLUSION:
This study provides evidence for the generalization of nine BMI and seven central adiposity loci in Hispanic women. This study expands the current knowledge of common adiposity-related genetic loci to Hispanic women.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23978819</pmid><doi>10.1038/nutd.2013.26</doi><oa>free_for_read</oa></addata></record> |
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| source | Springer Open Access; DOAJ Directory of Open Access Journals; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | 631/208/457/649 692/699/2743/393 Clinical Nutrition Diabetes Epidemiology Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Original original-article |
| title | Generalization of adiposity genetic loci to US Hispanic women |
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