Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change

Rationale Dopamine transporter (DAT) conformation plays a role in the effectiveness of cocaine-like and other DAT inhibitors. Cocaine-like stimulants are intolerant to DAT conformation changes having decreased potency in cells transfected with DAT constructs that face the cytosol compared to wild-ty...

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Veröffentlicht in:	Psychopharmacology 2013-09, Vol.229 (2), p.307-321
Hauptverfasser:	Tanda, Gianluigi, Li, Su Min, Mereu, Maddalena, Thomas, Alexandra M., Ebbs, Aaron L., Chun, Lauren E., Tronci, Valeria, Green, Jennifer L., Zou, Mu-Fa, Kopajtic, Theresa A., Newman, Amy Hauck, Katz, Jonathan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Benztropine - analogs & derivatives Benztropine - chemistry Benztropine - pharmacology Binding Sites - drug effects Biomedical and Life Sciences Biomedicine Cocaine Cocaine - pharmacology Conditioning, Operant - drug effects Dopamine Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug abuse Electric stimulation Health aspects Male Microdialysis Neurosciences Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Original Investigation Pharmacology/Toxicology Physiological aspects Protein Conformation - drug effects Psychiatry Psychopharmacology Radioligand Assay Rats Rats, Sprague-Dawley Rodents Time Factors
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