The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice

Polyphenols are representative bioactive substances with diverse biological effects. Here, we show that apigenin, a flavonoid, has suppressive effects on microRNA (miRNA) function. The effects were mediated by impaired maturation of a subset of miRNAs, probably through inhibition of the phosphorylat...

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Veröffentlicht in:	Scientific reports 2013-08, Vol.3 (1), p.2553-2553, Article 2553
Hauptverfasser:	Ohno, Motoko, Shibata, Chikako, Kishikawa, Takahiro, Yoshikawa, Takeshi, Takata, Akemi, Kojima, Kentaro, Akanuma, Masao, Kang, Young Jun, Yoshida, Haruhiko, Otsuka, Motoyuki, Koike, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/349 631/337/384/331 631/443/319/1642/137/773 631/80/86/2369 Animals Apigenin - administration & dosage Biological effects Caffeine - administration & dosage Extracellular signal-regulated kinase Flavonoids Glucose - pharmacology Glucose tolerance Glucose Tolerance Test Humanities and Social Sciences Insulin Resistance - physiology Intolerance Kinases Liver - drug effects Liver - metabolism MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Transgenic MicroRNAs MicroRNAs - metabolism miRNA multidisciplinary Phosphorylation Phosphorylation - drug effects Polyphenols Protein kinase Rodents Science Transgenic animals Transgenic mice
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