Significance of Glycosylphosphatidylinositol-anchored Protein Enrichment in Lipid Rafts for the Control of Autoimmunity

Glycosylphosphatidylinositols (GPI) are complex glycolipids that are covalently linked to the C terminus of proteins as a post-translational modification and tether proteins to the plasma membrane. One of the most striking features of GPI-anchored proteins (APs) is their enrichment in lipid rafts. T...

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Veröffentlicht in:	The Journal of biological chemistry 2013-08, Vol.288 (35), p.25490-25499
Hauptverfasser:	Wang, Yetao, Murakami, Yoshiko, Yasui, Teruhito, Wakana, Shigeharu, Kikutani, Hitoshi, Kinoshita, Taroh, Maeda, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Antinuclear - genetics Antibodies, Antinuclear - immunology Antibodies, Antinuclear - metabolism Apoptosis - genetics Apoptosis - immunology Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmune Diseases - pathology Autoimmunity B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Carboxylic Ester Hydrolases - genetics Carboxylic Ester Hydrolases - immunology Carboxylic Ester Hydrolases - metabolism Cells, Cultured Glomerular Mesangium - immunology Glomerular Mesangium - metabolism Glomerular Mesangium - pathology Glycosylphosphatidylinositol Anchors Glycosylphosphatidylinositols - genetics Glycosylphosphatidylinositols - immunology Glycosylphosphatidylinositols - metabolism Immune Complex Diseases - genetics Immune Complex Diseases - immunology Immune Complex Diseases - metabolism Lipid Raft Lipid Structure Lipids Membrane Microdomains - genetics Membrane Microdomains - immunology Membrane Microdomains - metabolism Membrane Microdomains - pathology Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, Knockout PGAP3 Phagocytosis Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology
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