The Bcl-2 Protein Family Member Bok Binds to the Coupling Domain of Inositol 1,4,5-Trisphosphate Receptors and Protects Them from Proteolytic Cleavage

Bok is a member of the Bcl-2 protein family that controls intrinsic apoptosis. Bok is most closely related to the pro-apoptotic proteins Bak and Bax, but in contrast to Bak and Bax, very little is known about its cellular role. Here we report that Bok binds strongly and constitutively to inositol 1,...

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Veröffentlicht in:	The Journal of biological chemistry 2013-08, Vol.288 (35), p.25340-25349
Hauptverfasser:	Schulman, Jacqualyn J., Wright, Forrest A., Kaufmann, Thomas, Wojcikiewicz, Richard J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Bcl-2 Family Proteins Bok Calcium - metabolism Caspase Caspase 3 - genetics Caspase 3 - metabolism Cell Line, Transformed Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism HeLa Cells Humans Inositol 1,4,5-Trisphosphate Inositol 1,4,5-Trisphosphate Receptor Inositol 1,4,5-Trisphosphate Receptors - genetics Inositol 1,4,5-Trisphosphate Receptors - metabolism Mice Mice, Knockout Protein Binding - physiology Protein Structure, Tertiary Proteolysis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction Ubiquitin
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