Betatrophin: a hormone that controls pancreatic β cell proliferation
Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expa...
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| Veröffentlicht in: | Cell 2013-05, Vol.153 (4), p.747-758 |
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| creator | Yi, Peng Park, Ji-Sun Melton, Douglas A |
| description | Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fat. Expression of betatrophin correlates with β cell proliferation in other mouse models of insulin resistance and during gestation. Transient expression of betatrophin in mouse liver significantly and specifically promotes pancreatic β cell proliferation, expands β cell mass, and improves glucose tolerance. Thus, betatrophin treatment could augment or replace insulin injections by increasing the number of endogenous insulin-producing cells in diabetics. |
| doi_str_mv | 10.1016/j.cell.2013.04.008 |
| format | Article |
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In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fat. Expression of betatrophin correlates with β cell proliferation in other mouse models of insulin resistance and during gestation. Transient expression of betatrophin in mouse liver significantly and specifically promotes pancreatic β cell proliferation, expands β cell mass, and improves glucose tolerance. Thus, betatrophin treatment could augment or replace insulin injections by increasing the number of endogenous insulin-producing cells in diabetics.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2013.04.008</identifier><identifier>PMID: 23623304</identifier><language>eng</language><publisher>United States</publisher><subject>Adipose Tissue, White - metabolism ; adults ; Amino Acid Sequence ; Angiopoietin-like Proteins ; animal models ; Animals ; Cell Proliferation ; Female ; Glucose - metabolism ; glucose tolerance ; Humans ; insulin ; Insulin Resistance ; Insulin-Secreting Cells - metabolism ; liver ; Liver - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Pancreas - cytology ; Pancreas - metabolism ; Peptide Hormones - chemistry ; Peptide Hormones - genetics ; Peptide Hormones - metabolism ; Peptides - administration & dosage ; pregnancy ; Receptor, Insulin - antagonists & inhibitors ; Sequence Alignment</subject><ispartof>Cell, 2013-05, Vol.153 (4), p.747-758</ispartof><rights>Copyright © 2013 Elsevier Inc. 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We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fat. Expression of betatrophin correlates with β cell proliferation in other mouse models of insulin resistance and during gestation. Transient expression of betatrophin in mouse liver significantly and specifically promotes pancreatic β cell proliferation, expands β cell mass, and improves glucose tolerance. Thus, betatrophin treatment could augment or replace insulin injections by increasing the number of endogenous insulin-producing cells in diabetics.</description><subject>Adipose Tissue, White - metabolism</subject><subject>adults</subject><subject>Amino Acid Sequence</subject><subject>Angiopoietin-like Proteins</subject><subject>animal models</subject><subject>Animals</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>glucose tolerance</subject><subject>Humans</subject><subject>insulin</subject><subject>Insulin Resistance</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Pancreas - cytology</subject><subject>Pancreas - metabolism</subject><subject>Peptide Hormones - chemistry</subject><subject>Peptide Hormones - genetics</subject><subject>Peptide Hormones - metabolism</subject><subject>Peptides - administration & dosage</subject><subject>pregnancy</subject><subject>Receptor, Insulin - antagonists & inhibitors</subject><subject>Sequence Alignment</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Kw0AUhQdRbK2-gAuZpZvEO_8TF4It9QcKbnQdJpOJSUkyMUkFX8sH8ZmcYhVdubpwz8e55x6ETgnEBIi8WMfW1XVMgbAYeAyg99CUQKIiThTdR1OAhEZaKj5BR8OwhkAIIQ7RhDJJGQM-Rcu5G83Y-66s2ktscOn7xrcOj6UZsfVtkOoBd6a1vTNjZfHHO95exV0QqsL1YenbY3RQmHpwJ7s5Q083y8fFXbR6uL1fXK-ijibJGCUclNXUaqELyiVzrACpCS1YBiSXjBFTZBnjKiMJt5popWSeCwa5zjJbcDZDV1--3SZrXG5dyGfqtOurxvRvqTdV-ldpqzJ99q8pU0IKAsHgfGfQ-5eNG8a0qYbtP6Z1fjOkNHREKJGC_osSJkAnoKUI6NnvWD95vmtmn1mjgTg</recordid><startdate>20130509</startdate><enddate>20130509</enddate><creator>Yi, Peng</creator><creator>Park, Ji-Sun</creator><creator>Melton, Douglas A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20130509</creationdate><title>Betatrophin: a hormone that controls pancreatic β cell proliferation</title><author>Yi, Peng ; Park, Ji-Sun ; Melton, Douglas A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p299t-9407c82c858f2463e3f06812f3b01d6331afbb347b194c818776dd530d8bbcf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipose Tissue, White - metabolism</topic><topic>adults</topic><topic>Amino Acid Sequence</topic><topic>Angiopoietin-like Proteins</topic><topic>animal models</topic><topic>Animals</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>glucose tolerance</topic><topic>Humans</topic><topic>insulin</topic><topic>Insulin Resistance</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Pancreas - cytology</topic><topic>Pancreas - metabolism</topic><topic>Peptide Hormones - chemistry</topic><topic>Peptide Hormones - genetics</topic><topic>Peptide Hormones - metabolism</topic><topic>Peptides - administration & dosage</topic><topic>pregnancy</topic><topic>Receptor, Insulin - antagonists & inhibitors</topic><topic>Sequence Alignment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yi, Peng</creatorcontrib><creatorcontrib>Park, Ji-Sun</creatorcontrib><creatorcontrib>Melton, Douglas A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yi, Peng</au><au>Park, Ji-Sun</au><au>Melton, Douglas A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Betatrophin: a hormone that controls pancreatic β cell proliferation</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2013-05-09</date><risdate>2013</risdate><volume>153</volume><issue>4</issue><spage>747</spage><epage>758</epage><pages>747-758</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fat. Expression of betatrophin correlates with β cell proliferation in other mouse models of insulin resistance and during gestation. Transient expression of betatrophin in mouse liver significantly and specifically promotes pancreatic β cell proliferation, expands β cell mass, and improves glucose tolerance. Thus, betatrophin treatment could augment or replace insulin injections by increasing the number of endogenous insulin-producing cells in diabetics.</abstract><cop>United States</cop><pmid>23623304</pmid><doi>10.1016/j.cell.2013.04.008</doi><tpages>12</tpages></addata></record> |
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| ispartof | Cell, 2013-05, Vol.153 (4), p.747-758 |
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| language | eng |
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| source | Electronic Journals Library; MEDLINE; Cell Press Archives; Elsevier ScienceDirect Journals |
| subjects | Adipose Tissue, White - metabolism adults Amino Acid Sequence Angiopoietin-like Proteins animal models Animals Cell Proliferation Female Glucose - metabolism glucose tolerance Humans insulin Insulin Resistance Insulin-Secreting Cells - metabolism liver Liver - metabolism Male Mice Mice, Inbred C57BL Molecular Sequence Data Pancreas - cytology Pancreas - metabolism Peptide Hormones - chemistry Peptide Hormones - genetics Peptide Hormones - metabolism Peptides - administration & dosage pregnancy Receptor, Insulin - antagonists & inhibitors Sequence Alignment |
| title | Betatrophin: a hormone that controls pancreatic β cell proliferation |
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