Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection

Rationale Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition. Objectives To examine the safety and efficacy of 28 days of once-daily Arikace in cystic fibrosis (CF) patients chronically infected with P aeruginosa....

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Veröffentlicht in:	Thorax 2013-09, Vol.68 (9), p.818-825
Hauptverfasser:	Clancy, J P, Dupont, L, Konstan, M W, Billings, J, Fustik, S, Goss, C H, Lymp, J, Minic, P, Quittner, A L, Rubenstein, R C, Young, K R, Saiman, L, Burns, J L, Govan, J R W, Ramsey, B, Gupta, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Amikacin - administration & dosage Amikacin - adverse effects Analysis of Variance Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibiotics Bacterial Infection Child Cystic Fibrosis Cystic Fibrosis - complications Cystic Fibrosis - physiopathology Double-Blind Method Drug dosages FDA approval Female Forced Expiratory Volume Humans Infections Liposomes Male Microbial Sensitivity Tests Mortality Mutation Nebulizers and Vaporizers Patients Pharmacokinetics Pseudomonas aeruginosa Pseudomonas Infections - drug therapy Quality of Life Respiratory Infection Sputum - microbiology Young Adult
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