Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness
We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT). Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2013-08, Vol.54 (8), p.5829-5835 |
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| container_title | Investigative ophthalmology & visual science |
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| creator | Zhang, Xiaolin Igo, Jr, Robert P Fondran, Jeremy Mootha, V Vinod Oliva, Matt Hammersmith, Kristin Sugar, Alan Lass, Jonathan H Iyengar, Sudha K |
| description | We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT).
Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT.
In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm).
Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted. |
| doi_str_mv | 10.1167/iovs.13-11918 |
| format | Article |
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Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT.
In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm).
Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.</description><identifier>ISSN: 1552-5783</identifier><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.13-11918</identifier><identifier>PMID: 23882692</identifier><language>eng</language><publisher>United States: The Association for Research in Vision and Ophthalmology</publisher><subject>Age Factors ; Aged ; Cohort Studies ; Cornea - pathology ; Diabetes Mellitus ; Female ; Fuchs' Endothelial Dystrophy - etiology ; Fuchs' Endothelial Dystrophy - pathology ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Risk Factors ; Smoking - adverse effects</subject><ispartof>Investigative ophthalmology & visual science, 2013-08, Vol.54 (8), p.5829-5835</ispartof><rights>Copyright 2013 The Association for Research in Vision and Ophthalmology, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-f8cd60ae128f0f3a68bf8c5cd07af7a6d53e5dac0bd3b14771a4dd61b2c50fb13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755540/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755540/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23882692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiaolin</creatorcontrib><creatorcontrib>Igo, Jr, Robert P</creatorcontrib><creatorcontrib>Fondran, Jeremy</creatorcontrib><creatorcontrib>Mootha, V Vinod</creatorcontrib><creatorcontrib>Oliva, Matt</creatorcontrib><creatorcontrib>Hammersmith, Kristin</creatorcontrib><creatorcontrib>Sugar, Alan</creatorcontrib><creatorcontrib>Lass, Jonathan H</creatorcontrib><creatorcontrib>Iyengar, Sudha K</creatorcontrib><creatorcontrib>Fuchs' Genetics Multi-Center Study Group</creatorcontrib><title>Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT).
Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT.
In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm).
Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Cohort Studies</subject><subject>Cornea - pathology</subject><subject>Diabetes Mellitus</subject><subject>Female</subject><subject>Fuchs' Endothelial Dystrophy - etiology</subject><subject>Fuchs' Endothelial Dystrophy - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><issn>1552-5783</issn><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtrHDEQhEVwiB_JMVejm3MZRy2NZuSLwSxxHDDkkpyFRg-PvLPSWq1ds_8-s37hnLrp-qhqKEK-AjsH6PrvMW_xHEQDcAHqAzkCKXkjeyUO3u2H5BjxnjEOwNkncsiFUry74Edke4WYbTQ15kRzoLjKy5juqEmO5jr6QkvEJQ3G1lyQPsY60uuNHfGM-uT2xBTNRG0uyc_T7bCWvB53FP3Wl1h3T06vch2jXSaP-Jl8DGZC_-VlnpC_1z_-LG6a298_fy2ubhsrVF-boKzrmPHAVWBBmE4N80lax3oTetM5Kbx0xrLBiQHavgfTOtfBwK1kYQBxQi6ffdebYeWd9akWM-l1iStTdjqbqP9XUhz1Xd5q0UspWzYbfHsxKPlh47HqVUTrp8kknzeooeVqjm3bdkabZ9SWjFh8eIsBpvdd6X1XGoR-6mrmT9__9ka_liP-Ac32lWY</recordid><startdate>20130827</startdate><enddate>20130827</enddate><creator>Zhang, Xiaolin</creator><creator>Igo, Jr, Robert P</creator><creator>Fondran, Jeremy</creator><creator>Mootha, V Vinod</creator><creator>Oliva, Matt</creator><creator>Hammersmith, Kristin</creator><creator>Sugar, Alan</creator><creator>Lass, Jonathan H</creator><creator>Iyengar, Sudha K</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130827</creationdate><title>Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness</title><author>Zhang, Xiaolin ; Igo, Jr, Robert P ; Fondran, Jeremy ; Mootha, V Vinod ; Oliva, Matt ; Hammersmith, Kristin ; Sugar, Alan ; Lass, Jonathan H ; Iyengar, Sudha K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-f8cd60ae128f0f3a68bf8c5cd07af7a6d53e5dac0bd3b14771a4dd61b2c50fb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Cohort Studies</topic><topic>Cornea - pathology</topic><topic>Diabetes Mellitus</topic><topic>Female</topic><topic>Fuchs' Endothelial Dystrophy - etiology</topic><topic>Fuchs' Endothelial Dystrophy - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaolin</creatorcontrib><creatorcontrib>Igo, Jr, Robert P</creatorcontrib><creatorcontrib>Fondran, Jeremy</creatorcontrib><creatorcontrib>Mootha, V Vinod</creatorcontrib><creatorcontrib>Oliva, Matt</creatorcontrib><creatorcontrib>Hammersmith, Kristin</creatorcontrib><creatorcontrib>Sugar, Alan</creatorcontrib><creatorcontrib>Lass, Jonathan H</creatorcontrib><creatorcontrib>Iyengar, Sudha K</creatorcontrib><creatorcontrib>Fuchs' Genetics Multi-Center Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaolin</au><au>Igo, Jr, Robert P</au><au>Fondran, Jeremy</au><au>Mootha, V Vinod</au><au>Oliva, Matt</au><au>Hammersmith, Kristin</au><au>Sugar, Alan</au><au>Lass, Jonathan H</au><au>Iyengar, Sudha K</au><aucorp>Fuchs' Genetics Multi-Center Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2013-08-27</date><risdate>2013</risdate><volume>54</volume><issue>8</issue><spage>5829</spage><epage>5835</epage><pages>5829-5835</pages><issn>1552-5783</issn><issn>0146-0404</issn><eissn>1552-5783</eissn><abstract>We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT).
Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT.
In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm).
Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>23882692</pmid><doi>10.1167/iovs.13-11918</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Age Factors Aged Cohort Studies Cornea - pathology Diabetes Mellitus Female Fuchs' Endothelial Dystrophy - etiology Fuchs' Endothelial Dystrophy - pathology Humans Male Middle Aged Multivariate Analysis Odds Ratio Risk Factors Smoking - adverse effects |
| title | Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness |
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