Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity
Using hemisphere-specific optogenetic activation of hippocampal fibers, this study finds that the magnitude of long-term potentiation in CA1 neurons depends on whether afferents originate in left or right CA3. Postsynaptic spines at CA3-CA1 synapses differ in glutamate receptor composition according...
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| Veröffentlicht in: | Nature neuroscience 2011-09, Vol.14 (11), p.1413-1415 |
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| creator | Kohl, Michael M Shipton, Olivia A Deacon, Robert M Rawlins, J Nicholas P Deisseroth, Karl Paulsen, Ole |
| description | Using hemisphere-specific optogenetic activation of hippocampal fibers, this study finds that the magnitude of long-term potentiation in CA1 neurons depends on whether afferents originate in left or right CA3.
Postsynaptic spines at CA3-CA1 synapses differ in glutamate receptor composition according to the hemispheric origin of CA3 afferents. To study the functional consequences of this asymmetry, we used optogenetic tools to selectively stimulate axons of CA3 pyramidal cells originating in either left or right mouse hippocampus. We found that left CA3 input produced more long-term potentiation at CA1 synapses than right CA3 input as a result of differential expression of GluN2B subunit–containing NMDA receptors. |
| doi_str_mv | 10.1038/nn.2915 |
| format | Article |
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Postsynaptic spines at CA3-CA1 synapses differ in glutamate receptor composition according to the hemispheric origin of CA3 afferents. To study the functional consequences of this asymmetry, we used optogenetic tools to selectively stimulate axons of CA3 pyramidal cells originating in either left or right mouse hippocampus. We found that left CA3 input produced more long-term potentiation at CA1 synapses than right CA3 input as a result of differential expression of GluN2B subunit–containing NMDA receptors.</description><subject>631/1647/2253</subject><subject>631/378/1595/1554</subject><subject>631/378/2591</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Asymmetry</subject><subject>Bacterial Proteins - genetics</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics - methods</subject><subject>brief-communication</subject><subject>CA1 Region, Hippocampal - cytology</subject><subject>CA3 Region, Hippocampal - physiology</subject><subject>Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics</subject><subject>Channelrhodopsins</subject><subject>Electric Stimulation - methods</subject><subject>Excitatory Postsynaptic Potentials - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohl, Michael M</au><au>Shipton, Olivia A</au><au>Deacon, Robert M</au><au>Rawlins, J Nicholas P</au><au>Deisseroth, Karl</au><au>Paulsen, Ole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2011-09-25</date><risdate>2011</risdate><volume>14</volume><issue>11</issue><spage>1413</spage><epage>1415</epage><pages>1413-1415</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Using hemisphere-specific optogenetic activation of hippocampal fibers, this study finds that the magnitude of long-term potentiation in CA1 neurons depends on whether afferents originate in left or right CA3.
Postsynaptic spines at CA3-CA1 synapses differ in glutamate receptor composition according to the hemispheric origin of CA3 afferents. To study the functional consequences of this asymmetry, we used optogenetic tools to selectively stimulate axons of CA3 pyramidal cells originating in either left or right mouse hippocampus. We found that left CA3 input produced more long-term potentiation at CA1 synapses than right CA3 input as a result of differential expression of GluN2B subunit–containing NMDA receptors.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>21946328</pmid><doi>10.1038/nn.2915</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/1647/2253 631/378/1595/1554 631/378/2591 Animal Genetics and Genomics Animals Animals, Newborn Asymmetry Bacterial Proteins - genetics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Biophysics - methods brief-communication CA1 Region, Hippocampal - cytology CA3 Region, Hippocampal - physiology Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics Channelrhodopsins Electric Stimulation - methods Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - genetics Functional Laterality - physiology Gene Expression Regulation - genetics Gene Expression Regulation - radiation effects In Vitro Techniques Kinases Life Sciences Light Luminescent Proteins - genetics Mice Mice, Transgenic Neurobiology Neuronal Plasticity - drug effects Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurons and Cognition Neurosciences Patch-Clamp Techniques - methods Physiology Pyramidal Cells - physiology Receptors, AMPA - genetics Receptors, AMPA - metabolism |
| title | Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity |
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