Tricellulin deficiency affects tight junction architecture and cochlear hair cells

The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to no...

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Veröffentlicht in:	The Journal of clinical investigation 2013-09, Vol.123 (9), p.4036-4049
Hauptverfasser:	Nayak, Gowri, Lee, Sue I, Yousaf, Rizwan, Edelmann, Stephanie E, Trincot, Claire, Van Itallie, Christina M, Sinha, Ghanshyam P, Rafeeq, Maria, Jones, Sherri M, Belyantseva, Inna A, Anderson, James M, Forge, Andrew, Frolenkov, Gregory I, Riazuddin, Saima
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Architecture Biomedical research Cell junctions Colleges & universities Epithelial cells Female Hair Hair cells (Mechanoreceptors) Hair Cells, Auditory, Outer - metabolism Hearing loss Hearing Loss - metabolism Hearing Loss - pathology Hematology Junctional complexes (Epithelium) Kinases Laboratory animals Male MARVEL Domain Containing 2 Protein - deficiency MARVEL Domain Containing 2 Protein - genetics Membrane Potentials Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Scanning Mutation Mutation, Missense Organ of Corti - pathology Physiological aspects Proteins Signal transduction Stria Vascularis - metabolism Stria Vascularis - pathology Tight Junctions - metabolism Vestibule, Labyrinth - metabolism Vestibule, Labyrinth - pathology
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