Inhibition of DNA damage repair by artificial activation of PARP with siDNA

One of the major early steps of repair is the recruitment of repair proteins at the damage site, and this is coordinated by a cascade of modifications controlled by phosphatidylinositol 3-kinase-related kinases and/or poly (ADP-ribose) polymerase (PARP). We used short interfering DNA molecules mimic...

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Veröffentlicht in:	Nucleic acids research 2013-08, Vol.41 (15), p.7344-7355
Hauptverfasser:	Croset, Amelie, Cordelières, Fabrice P, Berthault, Nathalie, Buhler, Cyril, Sun, Jian-Sheng, Quanz, Maria, Dutreix, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Benzimidazoles - pharmacology BRCA2 Protein - genetics BRCA2 Protein - metabolism DNA Breaks, Double-Stranded DNA Damage DNA Repair DNA-Activated Protein Kinase - genetics DNA-Activated Protein Kinase - metabolism Enzyme Activation Genome Integrity, Repair and Genome, Human HeLa Cells Humans Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphorylation Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Signal Transduction
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