Differential regulation of proliferation and neuronal differentiation in adult rat spinal cord neural stem/progenitors by ERK1/2, Akt, and PLCγ

Proliferation of endogenous neural stem/progenitor cells (NSPCs) has been identified in both normal and injured adult mammalian spinal cord. Yet the signaling mechanisms underlying the regulation of adult spinal cord NSPCs proliferation and commitment toward a neuronal lineage remain undefined. In t...

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Veröffentlicht in:	Frontiers in molecular neuroscience 2013-01, Vol.6, p.23-23
Hauptverfasser:	Chan, Wai Si, Sideris, Alexandra, Sutachan, Jhon J, Montoya G, Jose V, Blanck, Thomas J J, Recio-Pinto, Esperanza
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Antigens Apoptosis Cell culture Cell division Cell growth Cell proliferation Epidermal growth factor Extracellular signal-regulated kinase Fibroblast growth factor 2 Glutamatergic transmission Kinases MAP kinase Microtubule-associated protein 2 Morphology Neural stem cells Neurogenesis Neuroscience Phenotypes Phospholipase C Progenitor cells Protein kinase Signal transduction Spinal cord injuries Stem cells Synaptophysin
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