Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis

HSP70 is a member of the family of heat‐shock proteins that are known to be up‐regulated in neurons following injury and/or stress. HSP70 over‐expression has been linked to neuroprotection in multiple models, including neurodegenerative disorders. In contrast, less is known about the neuroprotective...

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Veröffentlicht in:	Journal of neurochemistry 2012-11, Vol.123 (4), p.542-554
Hauptverfasser:	Sabirzhanov, Boris, Stoica, Bogdan A., Hanscom, Marie, Piao, Chun-Shu, Faden, Alan I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death AIF Amyloid beta-Peptides - pharmacology Animals Apaf-1 Apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Caspases - metabolism Cell physiology Cells, Cultured Cerebral Cortex - cytology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Embryo, Mammalian Etoposide - pharmacology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Green Fluorescent Proteins - genetics HSP70 HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Immunoprecipitation Indexing in process Medical sciences Molecular and cellular biology Neural Inhibition - drug effects Neuroblastoma - pathology Neurochemistry Neurology Neurons Neurons - drug effects Neurons - metabolism neuroprotection Peptide Fragments - pharmacology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - metabolism Proteases Protein Binding - drug effects Rats Signal Transduction - drug effects Signal Transduction - physiology Sphingosine - analogs & derivatives Sphingosine - pharmacology Staurosporine - pharmacology Transfection
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