13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

Whereas intracellular carbon metabolism has emerged as an attractive drug target, the carbon sources of intracellularly replicating pathogens, such as the tuberculosis bacillus Mycobacterium tuberculosis, which causes long-term infections in one-third of the world’s population, remain mostly unknown...

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Veröffentlicht in:	Chemistry & biology 2013-08, Vol.20 (8), p.1012-1021
Hauptverfasser:	Beste, Dany J.V., Nöh, Katharina, Niedenführ, Sebastian, Mendum, Tom A., Hawkins, Nathaniel D., Ward, Jane L., Beale, Michael H., Wiechert, Wolfgang, McFadden, Johnjoe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Bacillus Carbon - analysis Carbon - metabolism Carbon Isotopes - analysis Carbon Isotopes - metabolism Cell Line Host-Pathogen Interactions Humans Macrophages - microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - physiology Tuberculosis - metabolism Tuberculosis - microbiology
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